| http://purl.uniprot.org/citations/19632221 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19632221 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19632221 | http://www.w3.org/2000/01/rdf-schema#comment | "The regulation of mast cell activities and survival is a central issue in inflammatory immune responses. Here, we have investigated the role of mouse interleukin-15, a pro-inflammatory and pleiotropic cytokine, in the control of mast cell survival and homeostasis. We report that aged IL-15-/-mice show a reduced number of peritoneal mast cells compared to WT mice. Furthermore, IL-15 deficiency in bone marrow derived mouse mast cells (BMMCs) results in increased susceptibility to apoptosis mediated by growth factor deprivation and A-SMase-treatment. IL-15-/-BMMCs show a constitutive stronger mRNA and protein expression as well as enzymatic activity of the members of the mitochondrial apoptotic pathways including acidic lysosomal aspartate protease cathepsin D (CTSD), endogenous acid sphingomyelinase (A-SMase), caspase-3 and -7 compared to wild type (WT) BMMCs. Furthermore, IL-15-/-BMMCs constitutively generate more A-SMase-derived ceramide than WT controls and display a decreased expression of pro-survival sphingosin-1-phosphate (SPP) both in cytosol and membrane cell fractions. Furthermore, pre-treatment of mast cells with imipramine or pepstatin A, inhibitors of the intracellular acid sphingomyelinase and cathepsin D pathways respectively, increases survival in IL-15-/-BMMCs. These findings suggest that intracellular IL-15 is a key regulator of pathways controlling primary mouse mast cell homeostasis."xsd:string |
| http://purl.uniprot.org/citations/19632221 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.yexcr.2009.07.019"xsd:string |
| http://purl.uniprot.org/citations/19632221 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.yexcr.2009.07.019"xsd:string |
| http://purl.uniprot.org/citations/19632221 | http://purl.uniprot.org/core/author | "Lee K.H."xsd:string |
| http://purl.uniprot.org/citations/19632221 | http://purl.uniprot.org/core/author | "Lee K.H."xsd:string |
| http://purl.uniprot.org/citations/19632221 | http://purl.uniprot.org/core/author | "Schuetze S."xsd:string |
| http://purl.uniprot.org/citations/19632221 | http://purl.uniprot.org/core/author | "Schuetze S."xsd:string |
| http://purl.uniprot.org/citations/19632221 | http://purl.uniprot.org/core/author | "Winoto-Morbach S."xsd:string |
| http://purl.uniprot.org/citations/19632221 | http://purl.uniprot.org/core/author | "Winoto-Morbach S."xsd:string |
| http://purl.uniprot.org/citations/19632221 | http://purl.uniprot.org/core/author | "Orinska Z."xsd:string |
| http://purl.uniprot.org/citations/19632221 | http://purl.uniprot.org/core/author | "Orinska Z."xsd:string |
| http://purl.uniprot.org/citations/19632221 | http://purl.uniprot.org/core/author | "Bulfone-Paus S."xsd:string |
| http://purl.uniprot.org/citations/19632221 | http://purl.uniprot.org/core/author | "Bulfone-Paus S."xsd:string |
| http://purl.uniprot.org/citations/19632221 | http://purl.uniprot.org/core/author | "Mirghomizadeh F."xsd:string |
| http://purl.uniprot.org/citations/19632221 | http://purl.uniprot.org/core/author | "Mirghomizadeh F."xsd:string |
| http://purl.uniprot.org/citations/19632221 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19632221 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19632221 | http://purl.uniprot.org/core/name | "Exp. Cell Res."xsd:string |
| http://purl.uniprot.org/citations/19632221 | http://purl.uniprot.org/core/name | "Exp. Cell Res."xsd:string |
| http://purl.uniprot.org/citations/19632221 | http://purl.uniprot.org/core/pages | "3064-3075"xsd:string |
| http://purl.uniprot.org/citations/19632221 | http://purl.uniprot.org/core/pages | "3064-3075"xsd:string |
| http://purl.uniprot.org/citations/19632221 | http://purl.uniprot.org/core/title | "Intracellular IL-15 controls mast cell survival."xsd:string |
| http://purl.uniprot.org/citations/19632221 | http://purl.uniprot.org/core/title | "Intracellular IL-15 controls mast cell survival."xsd:string |