| http://purl.uniprot.org/citations/19636373 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19636373 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19636373 | http://www.w3.org/2000/01/rdf-schema#comment | "This study provides a novel view on the interactions between the MS-KIF18A, a kinesin protein, and estrogen receptor alpha (ERalpha) which were studied in vivo and in vitro. Additionally, the regulation of MS-KIF18A expression by estrogen was investigated at the gene and protein levels. An association between recombinant proteins; ERalpha and MS-KIF18A was demonstrated in vitro in a pull down assay. Such interactions were proven also for endogenous proteins in MBA-15 cells were detected prominently in the cytoplasm and are up-regulated by estrogen. Additionally, an association between these proteins and the transcription factor NF-kappaB was identified. MS-KIF18A mRNA expression was measured in vivo in relation to age and estrogen level in mice and rats models. A decrease in MS-KIF18A mRNA level was measured in old and in OVX-estrogen depleted rats as compared to young animals. The low MS-KIF18A mRNA expression in OVX rats was restored by estrogen treatment. We studied the regulation of MS-KIF18A transcription by estrogen using the luciferase reporter gene and chromatin immuno-precipitation (ChIP) assays. The luciferase reporter gene assay demonstrated an increase in MS-KIF18A promoter activity in response to 10(-8) M estrogen and 10(-7)M ICI-182,780. Complimentary, the ChIP assay quantified the binding of ERalpha and pcJun to the MS-KIF18A promoter that was enhanced in cells treated by estrogen and ICI-182,780. In addition, cells treated by estrogen expressed higher levels of MS-KIF18A mRNA and protein and the protein turnover in MBA-15 cells was accelerated. Presented data demonstrated that ERalpha is a defined cargo of MS-KIF18A and added novel insight on the role of estrogen in regulation of MS-KIF18A expression both in vivo and in vitro."xsd:string |
| http://purl.uniprot.org/citations/19636373 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0006407"xsd:string |
| http://purl.uniprot.org/citations/19636373 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0006407"xsd:string |
| http://purl.uniprot.org/citations/19636373 | http://purl.uniprot.org/core/author | "Benayahu D."xsd:string |
| http://purl.uniprot.org/citations/19636373 | http://purl.uniprot.org/core/author | "Benayahu D."xsd:string |
| http://purl.uniprot.org/citations/19636373 | http://purl.uniprot.org/core/author | "Zusev M."xsd:string |
| http://purl.uniprot.org/citations/19636373 | http://purl.uniprot.org/core/author | "Zusev M."xsd:string |
| http://purl.uniprot.org/citations/19636373 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19636373 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19636373 | http://purl.uniprot.org/core/name | "PLoS ONE"xsd:string |
| http://purl.uniprot.org/citations/19636373 | http://purl.uniprot.org/core/name | "PLoS ONE"xsd:string |
| http://purl.uniprot.org/citations/19636373 | http://purl.uniprot.org/core/pages | "E6407"xsd:string |
| http://purl.uniprot.org/citations/19636373 | http://purl.uniprot.org/core/pages | "E6407"xsd:string |
| http://purl.uniprot.org/citations/19636373 | http://purl.uniprot.org/core/title | "The regulation of MS-KIF18A expression and cross talk with estrogen receptor."xsd:string |
| http://purl.uniprot.org/citations/19636373 | http://purl.uniprot.org/core/title | "The regulation of MS-KIF18A expression and cross talk with estrogen receptor."xsd:string |
| http://purl.uniprot.org/citations/19636373 | http://purl.uniprot.org/core/volume | "4"xsd:string |
| http://purl.uniprot.org/citations/19636373 | http://purl.uniprot.org/core/volume | "4"xsd:string |
| http://purl.uniprot.org/citations/19636373 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19636373 |
| http://purl.uniprot.org/citations/19636373 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19636373 |
| http://purl.uniprot.org/citations/19636373 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19636373 |
| http://purl.uniprot.org/citations/19636373 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19636373 |
| http://purl.uniprot.org/uniprot/P03372 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/19636373 |
| http://purl.uniprot.org/uniprot/Q8NI77 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/19636373 |