| http://purl.uniprot.org/citations/19638428 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19638428 | http://www.w3.org/2000/01/rdf-schema#comment | "Evidence points towards a pivotal role for cyclooxygenase (COX)-2 in promoting colorectal tumorigenesis through increasing prostaglandin E(2) (PGE(2)) levels. PGE(2) signalling is closely associated with the survival, proliferation and invasion of colorectal cancer cells. Recently, a reduction in PGE(2) inactivation, a process mediated by the nicotinamide adenine dinucleotide (NAD+)-dependent 15-hydroxyprostaglandin dehydrogenase (15-PGDH), has also been shown to promote tumoral PGE(2) accumulation. The hepatocyte growth factor (HGF) receptor, Met, is frequently over-expressed in colorectal tumours and promotes cancer growth, metastasis and resistance to therapy, although the mechanisms for this have not been fully elucidated. Here, we report that HGF/Met signalling can promote PGE(2) biogenesis in colorectal cancer cells via COX-2 up-regulation and 15-PGDH down-regulation at the protein and messenger RNA level. Pharmacological inhibition of MEK and PI3K suggested that both extracellular signal-regulated kinase (ERK) and AKT signalling are required for COX-2 protein up-regulation and 15-PGDH down-regulation downstream of Met. Notably, inhibition of Met with the small molecule inhibitor SU11274 reduced COX-2 expression and increased 15-PGDH expression in high Met-expressing cells. We also show that hypoxia potentiated HGF-driven COX-2 expression and enhanced PGE(2) release. Furthermore, inhibition of COX-2 impeded the growth-promoting effects of HGF, suggesting that the COX-2/PGE(2) pathway is an important mediator of HGF/Met signalling. These data reveal a critical role for HGF/Met signalling in promoting PGE(2) biogenesis in colorectal cancer cells. Targeting the crosstalk between these two important pathways may be useful for therapeutic treatment of colorectal cancer."xsd:string |
| http://purl.uniprot.org/citations/19638428 | http://purl.org/dc/terms/identifier | "doi:10.1093/carcin/bgp183"xsd:string |
| http://purl.uniprot.org/citations/19638428 | http://purl.uniprot.org/core/author | "Williams A.C."xsd:string |
| http://purl.uniprot.org/citations/19638428 | http://purl.uniprot.org/core/author | "Roberts H.R."xsd:string |
| http://purl.uniprot.org/citations/19638428 | http://purl.uniprot.org/core/author | "Hicks D.J."xsd:string |
| http://purl.uniprot.org/citations/19638428 | http://purl.uniprot.org/core/author | "Moore A.E."xsd:string |
| http://purl.uniprot.org/citations/19638428 | http://purl.uniprot.org/core/author | "Greenhough A."xsd:string |
| http://purl.uniprot.org/citations/19638428 | http://purl.uniprot.org/core/author | "Paraskeva C."xsd:string |
| http://purl.uniprot.org/citations/19638428 | http://purl.uniprot.org/core/author | "Patsos H.A."xsd:string |
| http://purl.uniprot.org/citations/19638428 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19638428 | http://purl.uniprot.org/core/name | "Carcinogenesis"xsd:string |
| http://purl.uniprot.org/citations/19638428 | http://purl.uniprot.org/core/pages | "1796-1804"xsd:string |
| http://purl.uniprot.org/citations/19638428 | http://purl.uniprot.org/core/title | "HGF/Met signalling promotes PGE(2) biogenesis via regulation of COX-2 and 15-PGDH expression in colorectal cancer cells."xsd:string |
| http://purl.uniprot.org/citations/19638428 | http://purl.uniprot.org/core/volume | "30"xsd:string |
| http://purl.uniprot.org/citations/19638428 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19638428 |
| http://purl.uniprot.org/citations/19638428 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19638428 |
| http://purl.uniprot.org/uniprot/#_D9MWI3-mappedCitation-19638428 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19638428 |
| http://purl.uniprot.org/uniprot/#_A5D6Q9-mappedCitation-19638428 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19638428 |
| http://purl.uniprot.org/uniprot/#_B5A935-mappedCitation-19638428 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19638428 |
| http://purl.uniprot.org/uniprot/#_B5A936-mappedCitation-19638428 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19638428 |
| http://purl.uniprot.org/uniprot/#_B5A937-mappedCitation-19638428 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19638428 |
| http://purl.uniprot.org/uniprot/#_B5A938-mappedCitation-19638428 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19638428 |
| http://purl.uniprot.org/uniprot/#_B5A939-mappedCitation-19638428 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19638428 |
| http://purl.uniprot.org/uniprot/#_B5A940-mappedCitation-19638428 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19638428 |