| http://purl.uniprot.org/citations/19639961 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19639961 | http://www.w3.org/2000/01/rdf-schema#comment | "The glycosyl-phosphatidylinositol anchored folate receptor (FR) mediates selective delivery of a broad range of experimental drugs to the receptor-rich tumors, but molecular mechanisms controlling FR internalization have not been adequately studied. FR quantitatively recycles between the cell surface and endocytic compartments via a Cdc42-dependent pinocytic pathway. Protein kinase C (PKC) activators including diacylglycerol and phorbol ester have previously been reported to increase the proportion of FR on the cell surface. Here we identify the alpha-subtype of PKC as the mediator of phorbol ester action on FR recycling and provide evidence that activated PKCalpha is recruited to FR-rich membrane microdomains where, in association with its receptor RACK1, it inhibits FR internalization; the activation state of Cdc42 remains unaltered. We also show that the PKC substrate, annexin II, is required for FR internalization. The studies clarify a molecular mechanism for the regulation of FR recycling through PKC which could potentially be exploited for effective drug delivery."xsd:string |
| http://purl.uniprot.org/citations/19639961 | http://purl.org/dc/terms/identifier | "doi:10.1021/bi900565t"xsd:string |
| http://purl.uniprot.org/citations/19639961 | http://purl.uniprot.org/core/author | "Zhang J."xsd:string |
| http://purl.uniprot.org/citations/19639961 | http://purl.uniprot.org/core/author | "Basrur V."xsd:string |
| http://purl.uniprot.org/citations/19639961 | http://purl.uniprot.org/core/author | "Ratnam M."xsd:string |
| http://purl.uniprot.org/citations/19639961 | http://purl.uniprot.org/core/author | "Gunning W."xsd:string |
| http://purl.uniprot.org/citations/19639961 | http://purl.uniprot.org/core/author | "Gonit M."xsd:string |
| http://purl.uniprot.org/citations/19639961 | http://purl.uniprot.org/core/author | "Elnakat H."xsd:string |
| http://purl.uniprot.org/citations/19639961 | http://purl.uniprot.org/core/author | "Kamen B."xsd:string |
| http://purl.uniprot.org/citations/19639961 | http://purl.uniprot.org/core/author | "Salazar M.D."xsd:string |
| http://purl.uniprot.org/citations/19639961 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19639961 | http://purl.uniprot.org/core/name | "Biochemistry"xsd:string |
| http://purl.uniprot.org/citations/19639961 | http://purl.uniprot.org/core/pages | "8249-8260"xsd:string |
| http://purl.uniprot.org/citations/19639961 | http://purl.uniprot.org/core/title | "Regulation of folate receptor internalization by protein kinase C alpha."xsd:string |
| http://purl.uniprot.org/citations/19639961 | http://purl.uniprot.org/core/volume | "48"xsd:string |
| http://purl.uniprot.org/citations/19639961 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19639961 |
| http://purl.uniprot.org/citations/19639961 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19639961 |
| http://purl.uniprot.org/uniprot/#_A0A169TED2-mappedCitation-19639961 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19639961 |
| http://purl.uniprot.org/uniprot/#_B0LPH5-mappedCitation-19639961 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19639961 |
| http://purl.uniprot.org/uniprot/#_Q7Z727-mappedCitation-19639961 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19639961 |
| http://purl.uniprot.org/uniprot/#_L7RSM7-mappedCitation-19639961 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19639961 |
| http://purl.uniprot.org/uniprot/#_P17252-mappedCitation-19639961 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19639961 |
| http://purl.uniprot.org/uniprot/#_Q2TSD3-mappedCitation-19639961 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19639961 |
| http://purl.uniprot.org/uniprot/#_Q59FI5-mappedCitation-19639961 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19639961 |