| http://purl.uniprot.org/citations/19640998 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19640998 | http://www.w3.org/2000/01/rdf-schema#comment | "The Epstein-Barr virus (EBV)-encoded RNAs, EBER-1 and EBER-2, are highly abundant noncoding nuclear RNAs expressed during all forms of EBV latency. The EBERs have been shown to impart significant tumorigenic potential upon EBV-negative Burkitt lymphoma (BL) cells and to contribute to the growth potential of other B-cell lymphoma-, gastric carcinoma-, and nasopharyngeal carcinoma-derived cell lines. However, the mechanisms underlying this EBER-dependent enhancement of cell growth potential remain to be elucidated. Here we focused on the known interaction between EBER-1 and the cellular ribosomal protein L22 and the consequences of this interaction with respect to the growth-promoting properties of the EBERs. L22, a component of 60S ribosomal subunits, binds three sites on EBER-1, and a substantial fraction of available L22 is relocalized from nucleoli to the nucleoplasm in EBV-infected cells. To investigate the hypothesis that EBER-1-mediated relocalization of L22 in EBV-infected cells is critical for EBER-dependent functions, we investigated whether EBER-1 expression is necessary and sufficient for nucleoplasmic retention of L22. Following demonstration of this, we utilized RNA-protein binding assays and fluorescence localization studies to demonstrate that mutation of the L22 binding sites on EBER-1 prevents L22 binding and inhibits EBER-1-dependent L22 relocalization. Finally, the in vivo consequence of preventing L22 relocalization in EBER-expressing cells was examined in soft agar colony formation assays. We demonstrate that BL cells expressing mutated EBER-1 RNAs rendered incapable of binding L22 have significantly reduced capacity to enhance cell growth potential relative to BL cells expressing wild-type EBERs."xsd:string |
| http://purl.uniprot.org/citations/19640998 | http://purl.org/dc/terms/identifier | "doi:10.1128/jvi.01014-09"xsd:string |
| http://purl.uniprot.org/citations/19640998 | http://purl.uniprot.org/core/author | "Ruf I.K."xsd:string |
| http://purl.uniprot.org/citations/19640998 | http://purl.uniprot.org/core/author | "Houmani J.L."xsd:string |
| http://purl.uniprot.org/citations/19640998 | http://purl.uniprot.org/core/author | "Davis C.I."xsd:string |
| http://purl.uniprot.org/citations/19640998 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19640998 | http://purl.uniprot.org/core/name | "J Virol"xsd:string |
| http://purl.uniprot.org/citations/19640998 | http://purl.uniprot.org/core/pages | "9844-9853"xsd:string |
| http://purl.uniprot.org/citations/19640998 | http://purl.uniprot.org/core/title | "Growth-promoting properties of Epstein-Barr virus EBER-1 RNA correlate with ribosomal protein L22 binding."xsd:string |
| http://purl.uniprot.org/citations/19640998 | http://purl.uniprot.org/core/volume | "83"xsd:string |
| http://purl.uniprot.org/citations/19640998 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19640998 |
| http://purl.uniprot.org/citations/19640998 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19640998 |
| http://purl.uniprot.org/uniprot/#_K7ERI7-mappedCitation-19640998 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19640998 |
| http://purl.uniprot.org/uniprot/#_P35268-mappedCitation-19640998 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19640998 |
| http://purl.uniprot.org/uniprot/#_Q9BYF5-mappedCitation-19640998 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19640998 |
| http://purl.uniprot.org/uniprot/#_Q8WYP0-mappedCitation-19640998 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19640998 |
| http://purl.uniprot.org/uniprot/P35268 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19640998 |
| http://purl.uniprot.org/uniprot/K7ERI7 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19640998 |
| http://purl.uniprot.org/uniprot/Q8WYP0 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19640998 |
| http://purl.uniprot.org/uniprot/Q9BYF5 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19640998 |