| http://purl.uniprot.org/citations/19647221 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19647221 | http://www.w3.org/2000/01/rdf-schema#comment | "Inappropriate drug delivery, secondary toxicities, and persistent chemo- and immunoresistance have traditionally compromised treatment response in melanoma. Using cellular systems and genetically engineered mouse models, we show that melanoma cells retain an innate ability to recognize cytosolic double-stranded RNA (dsRNA) and mount persistent stress response programs able to block tumor growth, even in highly immunosuppressed backgrounds. The dsRNA mimic polyinosine-polycytidylic acid, coadministered with polyethyleneimine as carrier, was identified as an unanticipated inducer of autophagy downstream of an exacerbated endosomal maturation program. A concurrent activity of the dsRNA helicase MDA-5 driving the proapoptotic protein NOXA resulted in an efficient autodigestion of melanoma cells. These results reveal tractable links for therapeutic intervention among dsRNA helicases, endo/lysosomes, and apoptotic factors."xsd:string |
| http://purl.uniprot.org/citations/19647221 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ccr.2009.07.004"xsd:string |
| http://purl.uniprot.org/citations/19647221 | http://purl.uniprot.org/core/author | "Checinska A."xsd:string |
| http://purl.uniprot.org/citations/19647221 | http://purl.uniprot.org/core/author | "Fisher P.B."xsd:string |
| http://purl.uniprot.org/citations/19647221 | http://purl.uniprot.org/core/author | "Soengas M.S."xsd:string |
| http://purl.uniprot.org/citations/19647221 | http://purl.uniprot.org/core/author | "Dash R."xsd:string |
| http://purl.uniprot.org/citations/19647221 | http://purl.uniprot.org/core/author | "Megias D."xsd:string |
| http://purl.uniprot.org/citations/19647221 | http://purl.uniprot.org/core/author | "Alonso-Curbelo D."xsd:string |
| http://purl.uniprot.org/citations/19647221 | http://purl.uniprot.org/core/author | "Calvo T.G."xsd:string |
| http://purl.uniprot.org/citations/19647221 | http://purl.uniprot.org/core/author | "Canon E."xsd:string |
| http://purl.uniprot.org/citations/19647221 | http://purl.uniprot.org/core/author | "Perez-Guijarro E."xsd:string |
| http://purl.uniprot.org/citations/19647221 | http://purl.uniprot.org/core/author | "Riveiro-Falkenbach E."xsd:string |
| http://purl.uniprot.org/citations/19647221 | http://purl.uniprot.org/core/author | "Rodriguez-Peralto J.L."xsd:string |
| http://purl.uniprot.org/citations/19647221 | http://purl.uniprot.org/core/author | "Barral P.M."xsd:string |
| http://purl.uniprot.org/citations/19647221 | http://purl.uniprot.org/core/author | "Piris M.A."xsd:string |
| http://purl.uniprot.org/citations/19647221 | http://purl.uniprot.org/core/author | "Larribere L."xsd:string |
| http://purl.uniprot.org/citations/19647221 | http://purl.uniprot.org/core/author | "Tuting T."xsd:string |
| http://purl.uniprot.org/citations/19647221 | http://purl.uniprot.org/core/author | "Tormo D."xsd:string |
| http://purl.uniprot.org/citations/19647221 | http://purl.uniprot.org/core/author | "Mulero F."xsd:string |
| http://purl.uniprot.org/citations/19647221 | http://purl.uniprot.org/core/author | "Ortiz-Romero P."xsd:string |
| http://purl.uniprot.org/citations/19647221 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19647221 | http://purl.uniprot.org/core/name | "Cancer Cell"xsd:string |
| http://purl.uniprot.org/citations/19647221 | http://purl.uniprot.org/core/pages | "103-114"xsd:string |
| http://purl.uniprot.org/citations/19647221 | http://purl.uniprot.org/core/title | "Targeted activation of innate immunity for therapeutic induction of autophagy and apoptosis in melanoma cells."xsd:string |