| http://purl.uniprot.org/citations/19647805 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19647805 | http://www.w3.org/2000/01/rdf-schema#comment | "Peroxiredoxin (Prx) I, a ubiquitous antioxidant enzyme, is known to protect against inflammation; however, its role in the allergic inflammation remains unidentified. We determined whether intristic Prx I protects against allergic asthma traits using Prx-I knockout (-/-) mice. Prx I (-/-) and wild-type (WT) mice were immunized with ovalbumin (OVA) plus aluminum potassium sulfate (Alum: Th2 adjuvant) and subsequently challenged with OVA. Twenty-four hours after the last OVA challenge, leukocyte influx including eosinophils into bronchoalveolar lavage fluid was significantly greater in Prx I (-/-) mice compared to that in WT mice. On the other hand, when these mice were immunized with OVA+complete Freund's adjuvant (Th1 adjuvant), opposite phenomenon was observed. In the presence of OVA/Alum, peribronchial inflammatory leukocyte infiltration, cholinergic airway resistance, and the lung expression of interleukin (IL)-2 were significantly greater and that of interferon-gamma was significantly lesser in Prx I (-/-) than in WT mice. In vitro, OVA/Alum-sensitized Prx I (-/-) T cells proliferated more profoundly than WT T cells when they were cocultured with syngeneic bone marrow-generated dendritic cells. These results indicate that endogenous Prx I protects against allergen-related Th2-type airway inflammation and hyperresponsiveness, at least partly, via the suppression of the lung expression of IL-2 and regulation of the Th1/Th2 balance in addition to its antioxidative properties. Furthermore, Prx I can inhibit allergen-specific T-cell proliferation through immunological synapse. Our findings implicate an alternative therapeutic value of Prx I in the treatment of Th2-skewed allergic airway inflammatory diseases such as atopic asthma."xsd:string |
| http://purl.uniprot.org/citations/19647805 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.intimp.2009.07.010"xsd:string |
| http://purl.uniprot.org/citations/19647805 | http://purl.uniprot.org/core/author | "Inoue K."xsd:string |
| http://purl.uniprot.org/citations/19647805 | http://purl.uniprot.org/core/author | "Takano H."xsd:string |
| http://purl.uniprot.org/citations/19647805 | http://purl.uniprot.org/core/author | "Ishii T."xsd:string |
| http://purl.uniprot.org/citations/19647805 | http://purl.uniprot.org/core/author | "Yanagawa T."xsd:string |
| http://purl.uniprot.org/citations/19647805 | http://purl.uniprot.org/core/author | "Yanagisawa R."xsd:string |
| http://purl.uniprot.org/citations/19647805 | http://purl.uniprot.org/core/author | "Koike E."xsd:string |
| http://purl.uniprot.org/citations/19647805 | http://purl.uniprot.org/core/author | "Warabi E."xsd:string |
| http://purl.uniprot.org/citations/19647805 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19647805 | http://purl.uniprot.org/core/name | "Int Immunopharmacol"xsd:string |
| http://purl.uniprot.org/citations/19647805 | http://purl.uniprot.org/core/pages | "1281-1288"xsd:string |
| http://purl.uniprot.org/citations/19647805 | http://purl.uniprot.org/core/title | "Peroxiredoxin I is a negative regulator of Th2-dominant allergic asthma."xsd:string |
| http://purl.uniprot.org/citations/19647805 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/19647805 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19647805 |
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