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http://purl.uniprot.org/citations/19651238http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/19651238http://www.w3.org/2000/01/rdf-schema#comment"Mouse esterase-x/carboxylesterase 1 (Es-x/Ces1) is a close homolog of triacylglycerol hydrolase/carboxylesterase 3 (TGH/Ces3). Es-x possesses a conserved esterase/lipase active site motif, suggesting that like TGH it could play a role in hepatic triacylglycerol (TG) metabolism. McArdle-RH7777 cells stably transfected with Es-x cDNA accumulated significantly less TG and had increased production of acid-soluble metabolites (an indicator of beta-oxidation) during incubations with 0.4mM oleic acid when compared to empty vector or TGH cDNA transfected cells. Reduction of cellular TG persisted in the presence of esterase/lipase inhibitor E600 indicating that Es-x-mediated TG lowering can be largely explained by reduced partitioning of exogenous fatty acids to TG and increased redirection to beta-oxidation, rather than by increased TG turnover. Glycerol supplementation increased TG synthesis in both control and Es-x expressing cells to similar extent suggesting that Es-x expression did not reduce flux of metabolic intermediates through the glycerol-3-phosphate pathway. While Es-x expression reduced cellular TG levels, secretion of TG and apolipoprotein B remained unchanged when compared to control cells. Overall, these results suggest that Es-x limits hepatic TG accumulation by promoting beta-oxidation."xsd:string
http://purl.uniprot.org/citations/19651238http://purl.org/dc/terms/identifier"doi:10.1016/j.bbalip.2009.07.006"xsd:string
http://purl.uniprot.org/citations/19651238http://purl.uniprot.org/core/author"Erickson B."xsd:string
http://purl.uniprot.org/citations/19651238http://purl.uniprot.org/core/author"Ko K.W."xsd:string
http://purl.uniprot.org/citations/19651238http://purl.uniprot.org/core/author"Lehner R."xsd:string
http://purl.uniprot.org/citations/19651238http://purl.uniprot.org/core/date"2009"xsd:gYear
http://purl.uniprot.org/citations/19651238http://purl.uniprot.org/core/name"Biochim Biophys Acta"xsd:string
http://purl.uniprot.org/citations/19651238http://purl.uniprot.org/core/pages"1133-1143"xsd:string
http://purl.uniprot.org/citations/19651238http://purl.uniprot.org/core/title"Es-x/Ces1 prevents triacylglycerol accumulation in McArdle-RH7777 hepatocytes."xsd:string
http://purl.uniprot.org/citations/19651238http://purl.uniprot.org/core/volume"1791"xsd:string
http://purl.uniprot.org/citations/19651238http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/19651238
http://purl.uniprot.org/citations/19651238http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/19651238
http://purl.uniprot.org/uniprot/#_A0A1D5RM42-mappedCitation-19651238http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/19651238
http://purl.uniprot.org/uniprot/#_P23953-mappedCitation-19651238http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/19651238
http://purl.uniprot.org/uniprot/#_Q3UW56-mappedCitation-19651238http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/19651238
http://purl.uniprot.org/uniprot/#_Q8VCC2-mappedCitation-19651238http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/19651238
http://purl.uniprot.org/uniprot/P23953http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/19651238
http://purl.uniprot.org/uniprot/A0A1D5RM42http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/19651238
http://purl.uniprot.org/uniprot/Q3UW56http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/19651238
http://purl.uniprot.org/uniprot/Q8VCC2http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/19651238