| http://purl.uniprot.org/citations/19651619 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19651619 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19651619 | http://www.w3.org/2000/01/rdf-schema#comment | "TGF-beta family members are highly pleiotropic cytokines with diverse regulatory functions. TGF-beta is normally found in the latent form associated with latency-associated peptide (LAP). This latent complex can associate with latent TGFbeta-binding protein (LTBP) to produce a large latent form. Latent TGF-beta is also found on the surface of activated FOXP3(+) regulatory T cells (Tregs), but it is unclear how it is anchored to the cell membrane. We show that GARP or LRRC32, a leucine-rich repeat molecule of unknown function, is critical for tethering TGF-beta to the cell surface. We demonstrate that platelets and activated Tregs co-express latent TGF-beta and GARP on their membranes. The knockdown of GARP mRNA with siRNA prevented surface latent TGF-beta expression on activated Tregs and recombinant latent TGF-beta1 is able to bind directly with GARP. Confocal microscopy and immunoprecipitation strongly support their interactions. The role of TGF-beta on Tregs appears to have dual functions, both for Treg-mediated suppression and infectious tolerance mechanism."xsd:string |
| http://purl.uniprot.org/citations/19651619 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0901944106"xsd:string |
| http://purl.uniprot.org/citations/19651619 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0901944106"xsd:string |
| http://purl.uniprot.org/citations/19651619 | http://purl.uniprot.org/core/author | "Wang R."xsd:string |
| http://purl.uniprot.org/citations/19651619 | http://purl.uniprot.org/core/author | "Wang R."xsd:string |
| http://purl.uniprot.org/citations/19651619 | http://purl.uniprot.org/core/author | "Unutmaz D."xsd:string |
| http://purl.uniprot.org/citations/19651619 | http://purl.uniprot.org/core/author | "Unutmaz D."xsd:string |
| http://purl.uniprot.org/citations/19651619 | http://purl.uniprot.org/core/author | "Andersson J."xsd:string |
| http://purl.uniprot.org/citations/19651619 | http://purl.uniprot.org/core/author | "Andersson J."xsd:string |
| http://purl.uniprot.org/citations/19651619 | http://purl.uniprot.org/core/author | "Shevach E.M."xsd:string |
| http://purl.uniprot.org/citations/19651619 | http://purl.uniprot.org/core/author | "Shevach E.M."xsd:string |
| http://purl.uniprot.org/citations/19651619 | http://purl.uniprot.org/core/author | "Ramsey H."xsd:string |
| http://purl.uniprot.org/citations/19651619 | http://purl.uniprot.org/core/author | "Ramsey H."xsd:string |
| http://purl.uniprot.org/citations/19651619 | http://purl.uniprot.org/core/author | "Tran D.Q."xsd:string |
| http://purl.uniprot.org/citations/19651619 | http://purl.uniprot.org/core/author | "Tran D.Q."xsd:string |
| http://purl.uniprot.org/citations/19651619 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19651619 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19651619 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/19651619 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/19651619 | http://purl.uniprot.org/core/pages | "13445-13450"xsd:string |
| http://purl.uniprot.org/citations/19651619 | http://purl.uniprot.org/core/pages | "13445-13450"xsd:string |
| http://purl.uniprot.org/citations/19651619 | http://purl.uniprot.org/core/title | "GARP (LRRC32) is essential for the surface expression of latent TGF-beta on platelets and activated FOXP3+ regulatory T cells."xsd:string |
| http://purl.uniprot.org/citations/19651619 | http://purl.uniprot.org/core/title | "GARP (LRRC32) is essential for the surface expression of latent TGF-beta on platelets and activated FOXP3+ regulatory T cells."xsd:string |