| http://purl.uniprot.org/citations/19652666 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19652666 | http://www.w3.org/2000/01/rdf-schema#comment | "Fibroblast growth factor (FGF) receptor substrate 2alpha (FRS2alpha) is the main mediator of signaling in the FGF pathway. Recent studies have shown that mitogen-activated protein kinase (MAPK) phosphorylates serine and threonine residues in FRS2, negatively affecting FGF-induced tyrosine phosphorylation (PY) of FRS2. Several kinds of stimuli can induce serine/threonine phosphorylation (PS/T) of FRS2, indicating that FRS2 may be useful for studying crosstalk between growth factor signaling pathways. Here, we report that FGF-induced PY of FRS2 can be attenuated by EGF co-stimulation in PC12 cells; this inhibitory effect could be completely reversed by U0126, an inhibitor of MEK. We further identified the ERK1/2-binding motif in FRS2 and generated FRS2-3KL, a mutant lacking MAPK binding and PT upon FGF and/or EGF stimulation. Unlike wild-type (WT) FRS2, FGF-induced PY of FRS2-3KL could not be inhibited by EGF co-stimulation, and FRS2-3KL-expressing PC12 cells exhibited more differentiating potential than FRS2-WT-expressing cells in response to FGF treatment. These results suggest that PS/T of FRS2 mediated by the FRS2-MAPK negative regulatory loop may function as a molecular switch integrating negative regulatory signals from other pathways into FGFR-generated signal transduction."xsd:string |
| http://purl.uniprot.org/citations/19652666 | http://purl.org/dc/terms/identifier | "doi:10.1038/cr.2009.95"xsd:string |
| http://purl.uniprot.org/citations/19652666 | http://purl.uniprot.org/core/author | "Chen Z."xsd:string |
| http://purl.uniprot.org/citations/19652666 | http://purl.uniprot.org/core/author | "Feng X."xsd:string |
| http://purl.uniprot.org/citations/19652666 | http://purl.uniprot.org/core/author | "Wu Y."xsd:string |
| http://purl.uniprot.org/citations/19652666 | http://purl.uniprot.org/core/author | "Zhang Z."xsd:string |
| http://purl.uniprot.org/citations/19652666 | http://purl.uniprot.org/core/author | "Zhou W."xsd:string |
| http://purl.uniprot.org/citations/19652666 | http://purl.uniprot.org/core/author | "Benge J."xsd:string |
| http://purl.uniprot.org/citations/19652666 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19652666 | http://purl.uniprot.org/core/name | "Cell Res"xsd:string |
| http://purl.uniprot.org/citations/19652666 | http://purl.uniprot.org/core/pages | "1165-1177"xsd:string |
| http://purl.uniprot.org/citations/19652666 | http://purl.uniprot.org/core/title | "FGF-receptor substrate 2 functions as a molecular sensor integrating external regulatory signals into the FGF pathway."xsd:string |
| http://purl.uniprot.org/citations/19652666 | http://purl.uniprot.org/core/volume | "19"xsd:string |
| http://purl.uniprot.org/citations/19652666 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19652666 |
| http://purl.uniprot.org/citations/19652666 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19652666 |
| http://purl.uniprot.org/uniprot/#_A0A384NQ31-mappedCitation-19652666 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19652666 |
| http://purl.uniprot.org/uniprot/#_P21781-mappedCitation-19652666 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19652666 |
| http://purl.uniprot.org/uniprot/#_P09038-mappedCitation-19652666 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19652666 |
| http://purl.uniprot.org/uniprot/#_O76093-mappedCitation-19652666 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19652666 |
| http://purl.uniprot.org/uniprot/#_L7RTG7-mappedCitation-19652666 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19652666 |
| http://purl.uniprot.org/uniprot/#_P27361-mappedCitation-19652666 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19652666 |
| http://purl.uniprot.org/uniprot/#_Q86Z14-mappedCitation-19652666 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19652666 |
| http://purl.uniprot.org/uniprot/#_Q9NP95-mappedCitation-19652666 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19652666 |
| http://purl.uniprot.org/uniprot/#_O43320-mappedCitation-19652666 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19652666 |