http://purl.uniprot.org/citations/19653131 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/19653131 | http://www.w3.org/2000/01/rdf-schema#comment | "Aggregated alpha-synuclein and the point mutations Ala30Pro and Ala53Thr of alpha-synuclein are associated with Parkinson's disease. The physiological roles of alpha-synuclein and methionine oxidation of the alpha-synuclein protein structure and function are not fully understood. Methionine sulfoxide reductase A (MsrA) reduces methionine sulfoxide residues and functions as an antioxidant. To monitor the effect of methionine oxidation to alpha-synuclein on basic cellular processes, alpha-synucleins were expressed in msrA null mutant and wild-type yeast cells. Protein degradation was inhibited in the alpha-synuclein-expressing msrA null mutant cells compared to alpha-synuclein-expressing wild-type cells. Increased inhibition of degradation and elevated accumulations of fibrillated proteins were observed in SynA30P-expressing msrA null mutant cells. Additionally, methionine oxidation inhibited alpha-synuclein phosphorylation in yeast cells and in vitro by casein kinase 2. Thus, a compromised MsrA function combined with alpha-synuclein overexpression may promote processes leading to synucleinopathies."xsd:string |
http://purl.uniprot.org/citations/19653131 | http://purl.org/dc/terms/identifier | "doi:10.1007/s12031-009-9274-8"xsd:string |
http://purl.uniprot.org/citations/19653131 | http://purl.uniprot.org/core/author | "Moskovitz J."xsd:string |
http://purl.uniprot.org/citations/19653131 | http://purl.uniprot.org/core/author | "Oien D.B."xsd:string |
http://purl.uniprot.org/citations/19653131 | http://purl.uniprot.org/core/author | "Moore D.S."xsd:string |
http://purl.uniprot.org/citations/19653131 | http://purl.uniprot.org/core/author | "Shinogle H.E."xsd:string |
http://purl.uniprot.org/citations/19653131 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
http://purl.uniprot.org/citations/19653131 | http://purl.uniprot.org/core/name | "J Mol Neurosci"xsd:string |
http://purl.uniprot.org/citations/19653131 | http://purl.uniprot.org/core/pages | "323-332"xsd:string |
http://purl.uniprot.org/citations/19653131 | http://purl.uniprot.org/core/title | "Clearance and phosphorylation of alpha-synuclein are inhibited in methionine sulfoxide reductase a null yeast cells."xsd:string |
http://purl.uniprot.org/citations/19653131 | http://purl.uniprot.org/core/volume | "39"xsd:string |
http://purl.uniprot.org/citations/19653131 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19653131 |
http://purl.uniprot.org/citations/19653131 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19653131 |
http://purl.uniprot.org/uniprot/#_A0A8H8ULB2-mappedCitation-19653131 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19653131 |
http://purl.uniprot.org/uniprot/#_P39692-mappedCitation-19653131 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19653131 |
http://purl.uniprot.org/uniprot/P39692 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19653131 |
http://purl.uniprot.org/uniprot/A0A8H8ULB2 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19653131 |