| http://purl.uniprot.org/citations/19653274 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19653274 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19653274 | http://www.w3.org/2000/01/rdf-schema#comment | "The lymphoid enhancer factor 1 (Lef-1) belongs to the nuclear transducers of canonical Wnt-signalling in embryogenesis and cancer. Lef-1 acts, in cooperation with beta-catenin, as a context-dependent transcriptional activator or repressor, thereby influencing multiple cellular functions such as proliferation, differentiation and migration. Here we report that an increased Lef-1 expression in human pancreatic cancer correlates with advanced tumour stages. In pancreatic tumours, two different transcripts of Lef-1 have been detected in various stages, as demonstrated by RT-PCR analysis. One transcript was identified as the full length Lef-1 (Lef-1 FL), whereas the second, shorter transcript lacked exon VI (Lef-1 Deltaexon VI) compared to the published sequence. Comparative analysis of these two Lef-1 variants revealed that they exhibit different cellular effects after transient expression in pancreatic carcinoma cells. Forced expression of Lef-1 Deltaexon VI inhibited E-cadherin expression in a beta-catenin-independent way. Increased amounts of Lef-1 Deltaexon VI resulted in reduced cellular aggregation and increased cell migration. Expression of Lef-1 FL, but not the newly identified Lef-1 Deltaexon VI, induced the expression of the cell cycle regulating proteins c-myc and cyclin D1 in cooperation with beta-catenin and it enhanced cell proliferation. Our findings indicate that expression of alternatively spliced Lef-1 isoforms is involved in the determination of proliferative or migratory characteristics of pancreatic carcinoma cells."xsd:string |
| http://purl.uniprot.org/citations/19653274 | http://purl.org/dc/terms/identifier | "doi:10.1002/ijc.24802"xsd:string |
| http://purl.uniprot.org/citations/19653274 | http://purl.org/dc/terms/identifier | "doi:10.1002/ijc.24802"xsd:string |
| http://purl.uniprot.org/citations/19653274 | http://purl.uniprot.org/core/author | "Koenig A."xsd:string |
| http://purl.uniprot.org/citations/19653274 | http://purl.uniprot.org/core/author | "Koenig A."xsd:string |
| http://purl.uniprot.org/citations/19653274 | http://purl.uniprot.org/core/author | "Menke A."xsd:string |
| http://purl.uniprot.org/citations/19653274 | http://purl.uniprot.org/core/author | "Menke A."xsd:string |
| http://purl.uniprot.org/citations/19653274 | http://purl.uniprot.org/core/author | "Ellenrieder V."xsd:string |
| http://purl.uniprot.org/citations/19653274 | http://purl.uniprot.org/core/author | "Ellenrieder V."xsd:string |
| http://purl.uniprot.org/citations/19653274 | http://purl.uniprot.org/core/author | "Jesse S."xsd:string |
| http://purl.uniprot.org/citations/19653274 | http://purl.uniprot.org/core/author | "Jesse S."xsd:string |
| http://purl.uniprot.org/citations/19653274 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/19653274 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/19653274 | http://purl.uniprot.org/core/name | "Int. J. Cancer"xsd:string |
| http://purl.uniprot.org/citations/19653274 | http://purl.uniprot.org/core/name | "Int. J. Cancer"xsd:string |
| http://purl.uniprot.org/citations/19653274 | http://purl.uniprot.org/core/pages | "1109-1120"xsd:string |
| http://purl.uniprot.org/citations/19653274 | http://purl.uniprot.org/core/pages | "1109-1120"xsd:string |
| http://purl.uniprot.org/citations/19653274 | http://purl.uniprot.org/core/title | "Lef-1 isoforms regulate different target genes and reduce cellular adhesion."xsd:string |
| http://purl.uniprot.org/citations/19653274 | http://purl.uniprot.org/core/title | "Lef-1 isoforms regulate different target genes and reduce cellular adhesion."xsd:string |
| http://purl.uniprot.org/citations/19653274 | http://purl.uniprot.org/core/volume | "126"xsd:string |
| http://purl.uniprot.org/citations/19653274 | http://purl.uniprot.org/core/volume | "126"xsd:string |
| http://purl.uniprot.org/citations/19653274 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19653274 |
| http://purl.uniprot.org/citations/19653274 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19653274 |