| http://purl.uniprot.org/citations/19654000 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19654000 | http://www.w3.org/2000/01/rdf-schema#comment | "Myocyte enhancer factor 2C (MEF2C) plays an important role in cardiovascular development and is a key transcription factor for cardiac hypertrophy. Here, we describe MEF2C regulation by insulin-like growth factor-1 (IGF-1) and its role in IGF-1-induced cardiac hypertrophy. We found that IGF-1 addition to cultured rat cardiomyocytes activated MEF2C, as evidenced by its increased nuclear localization and DNA binding activity. IGF-1 stimulated MEF2 dependent-gene transcription in a time-dependent manner, as indicated by increased MEF2 promoter-driven reporter gene activity; IGF-1 also induced p38-MAPK phosphorylation, while an inhibitor of p38-MAPK decreased both effects. Additionally, inhibitors of phosphatidylinositol 3-kinase and calcineurin prevented IGF-1-induced MEF2 transcriptional activity. Via MEF2C-dependent signaling, IGF-1 also stimulated transcription of atrial natriuretic factor and skeletal alpha-actin but not of fos-lux reporter genes. These novel data suggest that MEF2C activation by IGF-1 mediates the pro-hypertrophic effects of IGF-1 on cardiac gene expression."xsd:string |
| http://purl.uniprot.org/citations/19654000 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2009.07.147"xsd:string |
| http://purl.uniprot.org/citations/19654000 | http://purl.uniprot.org/core/author | "Chiong M."xsd:string |
| http://purl.uniprot.org/citations/19654000 | http://purl.uniprot.org/core/author | "Carrasco L."xsd:string |
| http://purl.uniprot.org/citations/19654000 | http://purl.uniprot.org/core/author | "Gonzalez L."xsd:string |
| http://purl.uniprot.org/citations/19654000 | http://purl.uniprot.org/core/author | "Bravo R."xsd:string |
| http://purl.uniprot.org/citations/19654000 | http://purl.uniprot.org/core/author | "Munoz J.P."xsd:string |
| http://purl.uniprot.org/citations/19654000 | http://purl.uniprot.org/core/author | "Hidalgo C."xsd:string |
| http://purl.uniprot.org/citations/19654000 | http://purl.uniprot.org/core/author | "Adasme T."xsd:string |
| http://purl.uniprot.org/citations/19654000 | http://purl.uniprot.org/core/author | "Maldonado C."xsd:string |
| http://purl.uniprot.org/citations/19654000 | http://purl.uniprot.org/core/author | "Diaz-Araya G."xsd:string |
| http://purl.uniprot.org/citations/19654000 | http://purl.uniprot.org/core/author | "Lavandero S."xsd:string |
| http://purl.uniprot.org/citations/19654000 | http://purl.uniprot.org/core/author | "Collao A."xsd:string |
| http://purl.uniprot.org/citations/19654000 | http://purl.uniprot.org/core/author | "Ocaranza P."xsd:string |
| http://purl.uniprot.org/citations/19654000 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19654000 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/19654000 | http://purl.uniprot.org/core/pages | "155-160"xsd:string |
| http://purl.uniprot.org/citations/19654000 | http://purl.uniprot.org/core/title | "The transcription factor MEF2C mediates cardiomyocyte hypertrophy induced by IGF-1 signaling."xsd:string |
| http://purl.uniprot.org/citations/19654000 | http://purl.uniprot.org/core/volume | "388"xsd:string |
| http://purl.uniprot.org/citations/19654000 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19654000 |
| http://purl.uniprot.org/citations/19654000 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19654000 |
| http://purl.uniprot.org/uniprot/P05019#attribution-C4CC13987148F4EC373C181AD86CD57B | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19654000 |
| http://purl.uniprot.org/uniprot/A0A096MJY4#attribution-0AFCA5147940CDE02DD50968649848D9 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19654000 |
| http://purl.uniprot.org/uniprot/A0A096MJY4#attribution-C4CC13987148F4EC373C181AD86CD57B | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19654000 |