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http://purl.uniprot.org/citations/19654554http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/19654554http://www.w3.org/2000/01/rdf-schema#comment"

Background

Two single nucleotide polymorphisms (SNPs) in adjacent genes, lymphotoxin alpha (LTA +252G, rs909253 A>G) and tumor necrosis factor (TNF -308A, rs1800629 G>A), form the G-A haplotype repeatedly associated with increased risk of non-Hodgkin lymphoma (NHL) in individuals uninfected with HIV-1. This association has been observed alone or in combination with human leukocyte antigens HLA-B*08 or HLA-DRB1*03 in the major histocompatibility complex (MHC). Which gene variant on this highly conserved extended haplotype (CEH 8.1) in whites most likely represents a true etiologic factor remains uncertain.

Objective

We aimed to determine whether the reported association of the G-A haplotype of LTA-TNF with non-AIDS NHL also occurs with AIDS-related NHL.

Methods

SNPs in LTA and TNF and in 6 other genes nearby were typed in 140 non-Hispanic European American pairs of AIDS-NHL cases and matched controls selected from HIV-infected men in the Multicenter AIDS Cohort Study.

Results

The G-A haplotype and a 4-SNP haplotype in the neighboring gene cluster (rs537160 (A) rs1270942 (G), rs2072633 (A), and rs6467 (C)) were associated with AIDS-NHL (odds ratio = 2.7, 95% confidence interval: 1.5 to 4.8, P = 0.0009; and odds ratio = 3.2, 95% confidence interval: 1.6 to 6.6, P = 0.0008; respectively). These 2 haplotypes occur in strong linkage disequilibrium with each other on CEH 8.1.

Conclusion

The CEH 8.1-specific haplotype association of MHC class III variants with AIDS-NHL closely resembles that observed for non-AIDS NHL. Corroboration of an MHC determinant of AIDS and non-AIDS NHL alike would imply an important pathogenetic mechanism common to both."xsd:string
http://purl.uniprot.org/citations/19654554http://purl.org/dc/terms/identifier"doi:10.1097/qai.0b013e3181b017d5"xsd:string
http://purl.uniprot.org/citations/19654554http://purl.uniprot.org/core/author"Tang J."xsd:string
http://purl.uniprot.org/citations/19654554http://purl.uniprot.org/core/author"Shrestha S."xsd:string
http://purl.uniprot.org/citations/19654554http://purl.uniprot.org/core/author"Wong H.L."xsd:string
http://purl.uniprot.org/citations/19654554http://purl.uniprot.org/core/author"Ambinder R.F."xsd:string
http://purl.uniprot.org/citations/19654554http://purl.uniprot.org/core/author"Kaslow R.A."xsd:string
http://purl.uniprot.org/citations/19654554http://purl.uniprot.org/core/author"Jacobson L.P."xsd:string
http://purl.uniprot.org/citations/19654554http://purl.uniprot.org/core/author"Martinez-Maza O."xsd:string
http://purl.uniprot.org/citations/19654554http://purl.uniprot.org/core/author"Rabkin C.S."xsd:string
http://purl.uniprot.org/citations/19654554http://purl.uniprot.org/core/author"Ogwaro K.M."xsd:string
http://purl.uniprot.org/citations/19654554http://purl.uniprot.org/core/author"Breen E.C."xsd:string
http://purl.uniprot.org/citations/19654554http://purl.uniprot.org/core/author"Aissani B."xsd:string
http://purl.uniprot.org/citations/19654554http://purl.uniprot.org/core/date"2009"xsd:gYear
http://purl.uniprot.org/citations/19654554http://purl.uniprot.org/core/name"J Acquir Immune Defic Syndr"xsd:string
http://purl.uniprot.org/citations/19654554http://purl.uniprot.org/core/pages"170-179"xsd:string
http://purl.uniprot.org/citations/19654554http://purl.uniprot.org/core/title"The major histocompatibility complex conserved extended haplotype 8.1 in AIDS-related non-Hodgkin lymphoma."xsd:string
http://purl.uniprot.org/citations/19654554http://purl.uniprot.org/core/volume"52"xsd:string
http://purl.uniprot.org/citations/19654554http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/19654554
http://purl.uniprot.org/citations/19654554http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/19654554
http://purl.uniprot.org/uniprot/#_A0A0A7C3H3-mappedCitation-19654554http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/19654554
http://purl.uniprot.org/uniprot/#_A0A0A7C3I1-mappedCitation-19654554http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/19654554
http://purl.uniprot.org/uniprot/#_A0A0A7C3I5-mappedCitation-19654554http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/19654554
http://purl.uniprot.org/uniprot/#_A0A0A0WDZ3-mappedCitation-19654554http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/19654554
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