| http://purl.uniprot.org/citations/19654941 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19654941 | http://www.w3.org/2000/01/rdf-schema#comment | "Idiopathic interstitial pneumonia (IIP) is characterized by varying degrees of interstitial fibrosis. IL-13 and IL-4 are strong inducers of tissue fibrosis, whereas IFN-gamma has antifibrotic potential. However, the roles of these substances in IIP remain unknown. IL-13, IL-4, and IFN-gamma were measured in the BAL fluid of 16 idiopathic pulmonary fibrosis (IPF) patients, 10 nonspecific interstitial pneumonia (NSIP) patients, and 8 normal controls. The expression of IL-13 and IL-13Ralpha1/alpha2 in lung tissues was analyzed using ELISA and immunohistochemistry. IL-13 levels were significantly higher in IPF patients than the others (P<0.05). IL-4 levels were higher in both IPF and NSIP patients than in normal controls (P<0.05), and IFN-gamma levels were lower in NSIP patients than in normal controls (P=0.047). IL-13 levels correlated inversely with FVC% (r=-0.47, P=0.043) and DLCO% (r=-0.58, P=0.014) in IPF and NSIP patients. IL-13 was strongly expressed in the smooth muscle, bronchial epithelium, alveolar macrophages and endothelium of IPF patients. IL-13Ralpha1, rather than IL-13Ralpha2, was strongly expressed in the smooth muscle, bronchial epithelium, and endothelium of IPF patients. IL-13 and its receptors may contribute to the pathogenesis of fibrosis in IIP and appear to be related to the severity of the disease."xsd:string |
| http://purl.uniprot.org/citations/19654941 | http://purl.org/dc/terms/identifier | "doi:10.3346/jkms.2009.24.4.614"xsd:string |
| http://purl.uniprot.org/citations/19654941 | http://purl.uniprot.org/core/author | "Kim Y.H."xsd:string |
| http://purl.uniprot.org/citations/19654941 | http://purl.uniprot.org/core/author | "Kim D.J."xsd:string |
| http://purl.uniprot.org/citations/19654941 | http://purl.uniprot.org/core/author | "Park C.S."xsd:string |
| http://purl.uniprot.org/citations/19654941 | http://purl.uniprot.org/core/author | "Park J.S."xsd:string |
| http://purl.uniprot.org/citations/19654941 | http://purl.uniprot.org/core/author | "Park S.W."xsd:string |
| http://purl.uniprot.org/citations/19654941 | http://purl.uniprot.org/core/author | "Paik S.H."xsd:string |
| http://purl.uniprot.org/citations/19654941 | http://purl.uniprot.org/core/author | "Jang H.K."xsd:string |
| http://purl.uniprot.org/citations/19654941 | http://purl.uniprot.org/core/author | "Ahn M.H."xsd:string |
| http://purl.uniprot.org/citations/19654941 | http://purl.uniprot.org/core/author | "Shin H.K."xsd:string |
| http://purl.uniprot.org/citations/19654941 | http://purl.uniprot.org/core/author | "Uh S.T."xsd:string |
| http://purl.uniprot.org/citations/19654941 | http://purl.uniprot.org/core/author | "Jang A.S."xsd:string |
| http://purl.uniprot.org/citations/19654941 | http://purl.uniprot.org/core/author | "Koh E.S."xsd:string |
| http://purl.uniprot.org/citations/19654941 | http://purl.uniprot.org/core/author | "Park J.S.'"xsd:string |
| http://purl.uniprot.org/citations/19654941 | http://purl.uniprot.org/core/author | "Youm W."xsd:string |
| http://purl.uniprot.org/citations/19654941 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19654941 | http://purl.uniprot.org/core/name | "J Korean Med Sci"xsd:string |
| http://purl.uniprot.org/citations/19654941 | http://purl.uniprot.org/core/pages | "614-620"xsd:string |
| http://purl.uniprot.org/citations/19654941 | http://purl.uniprot.org/core/title | "Interleukin-13 and its receptors in idiopathic interstitial pneumonia: clinical implications for lung function."xsd:string |
| http://purl.uniprot.org/citations/19654941 | http://purl.uniprot.org/core/volume | "24"xsd:string |
| http://purl.uniprot.org/citations/19654941 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19654941 |
| http://purl.uniprot.org/citations/19654941 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19654941 |
| http://purl.uniprot.org/uniprot/#_D0EFR8-mappedCitation-19654941 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19654941 |