| http://purl.uniprot.org/citations/19656157 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19656157 | http://www.w3.org/2000/01/rdf-schema#comment | "BCSC-1 is dramatically upregulated in CNE-2L2 human nasopharyngeal carcinoma cells with reduced malignancy (AS cells) and is proposed to be a candidate tumor suppressor gene. We therefore examined the effect of BCSC-1 expression on malignant behaviors of CNE-2L2 cells. Growth in vitro and tumorigenesis in nude mice of wild-type CNE-2L2 cells (W cells) were inhibited by ectopic BCSC-1, and those of AS cells were promoted by BCSC-1 suppression. The tumor suppressor function of BCSC-1 was further confirmed by a study showing that intratumor BCSC-1 injection caused growth suppression of the tumor from W cells inoculated in nude mice. Immunohistochemistry exhibited marked reduction of BCSC-1 expression in 11 of 39 human nasopharyngeal carcinoma specimens. Because BCSC-1 expression was as rich as that in normal cells in the rest of the carcinoma specimens and was poor in CNE-2L2 cells, HNE-1 human nasopharyngeal carcinoma cells with rich BCSC-1 expression were used as a control in the study. No effect of BCSC-1 transfection on growth of the cells was observed. The data suggest that BCSC-1 suppression might play roles in tumorigenesis of some nasopharyngeal carcinomas and that BCSC-1 might be a potential gene therapy target in nasopharyngeal carcinomas with poor BCSC-1 expression. Enhanced aggregation of cells together with increased E-cadherin and alpha-catenin expression and reduced Wnt signaling might be involved in the mechanisms of tumor suppressor function of BCSC-1."xsd:string |
| http://purl.uniprot.org/citations/19656157 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1349-7006.2009.01261.x"xsd:string |
| http://purl.uniprot.org/citations/19656157 | http://purl.uniprot.org/core/author | "Chen S.L."xsd:string |
| http://purl.uniprot.org/citations/19656157 | http://purl.uniprot.org/core/author | "He Z.G."xsd:string |
| http://purl.uniprot.org/citations/19656157 | http://purl.uniprot.org/core/author | "Liu Y."xsd:string |
| http://purl.uniprot.org/citations/19656157 | http://purl.uniprot.org/core/author | "Shen L."xsd:string |
| http://purl.uniprot.org/citations/19656157 | http://purl.uniprot.org/core/author | "Zhou Y.Q."xsd:string |
| http://purl.uniprot.org/citations/19656157 | http://purl.uniprot.org/core/author | "Zhu L.P."xsd:string |
| http://purl.uniprot.org/citations/19656157 | http://purl.uniprot.org/core/author | "Zhen S."xsd:string |
| http://purl.uniprot.org/citations/19656157 | http://purl.uniprot.org/core/author | "Lv N."xsd:string |
| http://purl.uniprot.org/citations/19656157 | http://purl.uniprot.org/core/author | "Ju J.Y."xsd:string |
| http://purl.uniprot.org/citations/19656157 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19656157 | http://purl.uniprot.org/core/name | "Cancer Sci"xsd:string |
| http://purl.uniprot.org/citations/19656157 | http://purl.uniprot.org/core/pages | "1817-1822"xsd:string |
| http://purl.uniprot.org/citations/19656157 | http://purl.uniprot.org/core/title | "Tumor suppressor function of BCSC-1 in nasopharyngeal carcinoma."xsd:string |
| http://purl.uniprot.org/citations/19656157 | http://purl.uniprot.org/core/volume | "100"xsd:string |
| http://purl.uniprot.org/citations/19656157 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19656157 |
| http://purl.uniprot.org/citations/19656157 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19656157 |
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| http://purl.uniprot.org/uniprot/#_A0A0U2ZQU7-mappedCitation-19656157 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19656157 |
| http://purl.uniprot.org/uniprot/#_A0A140HMB1-mappedCitation-19656157 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19656157 |
| http://purl.uniprot.org/uniprot/#_A0A384MDY0-mappedCitation-19656157 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19656157 |
| http://purl.uniprot.org/uniprot/#_B3KSR8-mappedCitation-19656157 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19656157 |
| http://purl.uniprot.org/uniprot/#_A0A3G2JNR5-mappedCitation-19656157 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19656157 |