RDF/XMLNTriplesTurtleShow queryShare
SubjectPredicateObject
http://purl.uniprot.org/citations/19656853http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/19656853http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/19656853http://www.w3.org/2000/01/rdf-schema#comment"Udu has been shown to play an essential role during blood cell development; however, its roles in other cellular processes remain largely unexplored. In addition, ugly duckling (udu) mutants exhibited somite and myotome boundary defects. Our fluorescence-activated cell sorting analysis also showed that the loss of udu function resulted in defective cell cycle progression and comet assay indicated the presence of increased DNA damage in udu(tu24) mutants. We further showed that the extensive p53-dependent apoptosis in udu(tu24) mutants is a consequence of activation in the Atm-Chk2 pathway. Udu seems not to be required for DNA repair, because both wild-type and udu embryos similarly respond to and recover from UV treatment. Yeast two-hybrid and coimmunoprecipitation data demonstrated that PAH-L repeats and SANT-L domain of Udu interacts with MCM3 and MCM4. Furthermore, Udu is colocalized with 5-bromo-2'-deoxyuridine and heterochromatin during DNA replication, suggesting a role in maintaining genome integrity."xsd:string
http://purl.uniprot.org/citations/19656853http://purl.org/dc/terms/identifier"doi:10.1091/mbc.e09-02-0109"xsd:string
http://purl.uniprot.org/citations/19656853http://purl.uniprot.org/core/author"Jiang Y.J."xsd:string
http://purl.uniprot.org/citations/19656853http://purl.uniprot.org/core/author"Jiang Y.J."xsd:string
http://purl.uniprot.org/citations/19656853http://purl.uniprot.org/core/author"Lim C.H."xsd:string
http://purl.uniprot.org/citations/19656853http://purl.uniprot.org/core/author"Lim C.H."xsd:string
http://purl.uniprot.org/citations/19656853http://purl.uniprot.org/core/author"Chong S.W."xsd:string
http://purl.uniprot.org/citations/19656853http://purl.uniprot.org/core/author"Chong S.W."xsd:string
http://purl.uniprot.org/citations/19656853http://purl.uniprot.org/core/date"2009"xsd:gYear
http://purl.uniprot.org/citations/19656853http://purl.uniprot.org/core/date"2009"xsd:gYear
http://purl.uniprot.org/citations/19656853http://purl.uniprot.org/core/name"Mol. Biol. Cell"xsd:string
http://purl.uniprot.org/citations/19656853http://purl.uniprot.org/core/name"Mol Biol Cell"xsd:string
http://purl.uniprot.org/citations/19656853http://purl.uniprot.org/core/pages"4183-4193"xsd:string
http://purl.uniprot.org/citations/19656853http://purl.uniprot.org/core/pages"4183-4193"xsd:string
http://purl.uniprot.org/citations/19656853http://purl.uniprot.org/core/title"Udu deficiency activates DNA damage checkpoint."xsd:string
http://purl.uniprot.org/citations/19656853http://purl.uniprot.org/core/title"Udu deficiency activates DNA damage checkpoint."xsd:string
http://purl.uniprot.org/citations/19656853http://purl.uniprot.org/core/volume"20"xsd:string
http://purl.uniprot.org/citations/19656853http://purl.uniprot.org/core/volume"20"xsd:string
http://purl.uniprot.org/citations/19656853http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/19656853
http://purl.uniprot.org/citations/19656853http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/19656853
http://purl.uniprot.org/citations/19656853http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/19656853
http://purl.uniprot.org/citations/19656853http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/19656853
http://purl.uniprot.org/uniprot/Q5RIC5http://purl.uniprot.org/core/citationhttp://purl.uniprot.org/citations/19656853