| http://purl.uniprot.org/citations/19663908 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19663908 | http://www.w3.org/2000/01/rdf-schema#comment | "Mutations in the E3 ubiquitin ligase parkin cause early-onset, autosomal-recessive juvenile parkinsonism (AJRP), presumably as a result of a lack of function that alters the level, activity, aggregation or localization of its substrates. Recently, we have reported that phospholipase Cgamma1 is a substrate for parkin. In this article, we show that parkin mutants and siRNA parkin knockdown cells possess enhanced levels of phospholipase Cgamma1 phosphorylation, basal phosphoinositide hydrolysis and intracellular Ca2+ concentration. The protein levels of Ca2+-regulated protein kinase Calpha were decreased in AJRP parkin mutant cells. Neomycin and dantrolene both decreased the intracellular Ca2+ levels in parkin mutants in comparison with those seen in wild-type parkin cells, suggesting that the differences were a consequence of altered phospholipase C activity. The protection of wild-type parkin against 6-hydroxydopamine (6OHDA) toxicity was also established in ARJP mutants on pretreatment with dantrolene, implying that a balancing Ca2+ release from ryanodine-sensitive stores decreases the toxic effects of 6OHDA. Our findings suggest that parkin is an important factor for maintaining Ca2+ homeostasis and that parkin deficiency leads to a phospholipase C-dependent increase in intracellular Ca2+ levels, which make cells more vulnerable to neurotoxins, such as 6OHDA."xsd:string |
| http://purl.uniprot.org/citations/19663908 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1742-4658.2009.07201.x"xsd:string |
| http://purl.uniprot.org/citations/19663908 | http://purl.uniprot.org/core/author | "Cookson M.R."xsd:string |
| http://purl.uniprot.org/citations/19663908 | http://purl.uniprot.org/core/author | "Thomas K.J."xsd:string |
| http://purl.uniprot.org/citations/19663908 | http://purl.uniprot.org/core/author | "Cowburn R.F."xsd:string |
| http://purl.uniprot.org/citations/19663908 | http://purl.uniprot.org/core/author | "Cedazo-Minguez A."xsd:string |
| http://purl.uniprot.org/citations/19663908 | http://purl.uniprot.org/core/author | "Dehvari N."xsd:string |
| http://purl.uniprot.org/citations/19663908 | http://purl.uniprot.org/core/author | "Perez-Manso M."xsd:string |
| http://purl.uniprot.org/citations/19663908 | http://purl.uniprot.org/core/author | "Sandebring A."xsd:string |
| http://purl.uniprot.org/citations/19663908 | http://purl.uniprot.org/core/author | "Karpilovski E."xsd:string |
| http://purl.uniprot.org/citations/19663908 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19663908 | http://purl.uniprot.org/core/name | "FEBS J"xsd:string |
| http://purl.uniprot.org/citations/19663908 | http://purl.uniprot.org/core/pages | "5041-5052"xsd:string |
| http://purl.uniprot.org/citations/19663908 | http://purl.uniprot.org/core/title | "Parkin deficiency disrupts calcium homeostasis by modulating phospholipase C signalling."xsd:string |
| http://purl.uniprot.org/citations/19663908 | http://purl.uniprot.org/core/volume | "276"xsd:string |
| http://purl.uniprot.org/citations/19663908 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19663908 |
| http://purl.uniprot.org/citations/19663908 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19663908 |
| http://purl.uniprot.org/uniprot/#_D3JZW5-mappedCitation-19663908 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19663908 |
| http://purl.uniprot.org/uniprot/#_D3K2X1-mappedCitation-19663908 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19663908 |
| http://purl.uniprot.org/uniprot/#_D3K2X2-mappedCitation-19663908 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19663908 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z446-mappedCitation-19663908 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19663908 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z447-mappedCitation-19663908 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19663908 |
| http://purl.uniprot.org/uniprot/#_A0A1W5XGD7-mappedCitation-19663908 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19663908 |
| http://purl.uniprot.org/uniprot/#_A0A1W5XGE1-mappedCitation-19663908 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19663908 |