| http://purl.uniprot.org/citations/19666031 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19666031 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19666031 | http://www.w3.org/2000/01/rdf-schema#comment | "The neuronal scaffolding protein AIDA-1 is believed to act as a convener of signals arising at postsynaptic densities. Among the readily identifiable domains in AIDA-1, two closely juxtaposed sterile alpha motif (SAM) domains and a phosphotyrosine binding domain are located within the C-terminus of the longest splice variant and exclusively in four shorter splice variants. As a first step towards understanding the possible emergent properties arising from this assembly of ligand binding domains, we have used NMR methods to solve the first structure of a SAM domain tandem. Separated by a 15-aa linker, the two SAM domains are fused in a head-to-tail orientation that has been observed in other hetero- and homotypic SAM domain structures. The basic nuclear import signal for AIDA-1 is buried at the interface between the two SAM domains. An observed disparity between the thermal stabilities of the two SAM domains suggests a mechanism whereby the second SAM domain decouples from the first SAM domain to facilitate translocation of AIDA-1 to the nucleus."xsd:string |
| http://purl.uniprot.org/citations/19666031 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.jmb.2009.08.004"xsd:string |
| http://purl.uniprot.org/citations/19666031 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.jmb.2009.08.004"xsd:string |
| http://purl.uniprot.org/citations/19666031 | http://purl.uniprot.org/core/author | "Mobli M."xsd:string |
| http://purl.uniprot.org/citations/19666031 | http://purl.uniprot.org/core/author | "Mobli M."xsd:string |
| http://purl.uniprot.org/citations/19666031 | http://purl.uniprot.org/core/author | "Donaldson L.W."xsd:string |
| http://purl.uniprot.org/citations/19666031 | http://purl.uniprot.org/core/author | "Donaldson L.W."xsd:string |
| http://purl.uniprot.org/citations/19666031 | http://purl.uniprot.org/core/author | "Brener S."xsd:string |
| http://purl.uniprot.org/citations/19666031 | http://purl.uniprot.org/core/author | "Brener S."xsd:string |
| http://purl.uniprot.org/citations/19666031 | http://purl.uniprot.org/core/author | "Kurabi A."xsd:string |
| http://purl.uniprot.org/citations/19666031 | http://purl.uniprot.org/core/author | "Kurabi A."xsd:string |
| http://purl.uniprot.org/citations/19666031 | http://purl.uniprot.org/core/author | "Kwan J.J."xsd:string |
| http://purl.uniprot.org/citations/19666031 | http://purl.uniprot.org/core/author | "Kwan J.J."xsd:string |
| http://purl.uniprot.org/citations/19666031 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19666031 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19666031 | http://purl.uniprot.org/core/name | "J. Mol. Biol."xsd:string |
| http://purl.uniprot.org/citations/19666031 | http://purl.uniprot.org/core/name | "J. Mol. Biol."xsd:string |
| http://purl.uniprot.org/citations/19666031 | http://purl.uniprot.org/core/pages | "1168-1177"xsd:string |
| http://purl.uniprot.org/citations/19666031 | http://purl.uniprot.org/core/pages | "1168-1177"xsd:string |
| http://purl.uniprot.org/citations/19666031 | http://purl.uniprot.org/core/title | "A nuclear localization signal at the SAM-SAM domain interface of AIDA-1 suggests a requirement for domain uncoupling prior to nuclear import."xsd:string |
| http://purl.uniprot.org/citations/19666031 | http://purl.uniprot.org/core/title | "A nuclear localization signal at the SAM-SAM domain interface of AIDA-1 suggests a requirement for domain uncoupling prior to nuclear import."xsd:string |
| http://purl.uniprot.org/citations/19666031 | http://purl.uniprot.org/core/volume | "392"xsd:string |
| http://purl.uniprot.org/citations/19666031 | http://purl.uniprot.org/core/volume | "392"xsd:string |