| http://purl.uniprot.org/citations/19668225 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19668225 | http://www.w3.org/2000/01/rdf-schema#comment | "ErbB2 has been shown to activate signaling molecules that may regulate glucose metabolism. However, there is no evidence reported to directly link ErbB2 to glycolysis, and the mechanism underlying ErbB2-enhanced glycolysis is poorly understood. In this study, we investigated the role and mechanism of ErbB2 in regulating glycolysis. We found that ErbB2-overexpressing cells possessed a significantly higher level of glycolysis when compared to the ErbB2-low-expressing cells, and the downregulation of ErbB2 markedly decreased glycolysis. Overexpression of ErbB2 increased the expression of glycolysis-regulating molecules lactate dehydrogenase A (LDH-A) and heat shock factor 1 (HSF1). ErbB2 activated HSF1, indicated by the increased HSF1 trimer formation, and promoted HSF1 protein synthesis. HSF1 bound to LDH-A promoter and the downregulation of HSF1 reduced the expression of LDH-A and subsequently decreased cancer cell glycolysis and growth. Moreover, the glycolysis inhibitors, 2-deoxyglucose and oxamate, selectively inhibited the growth of ErbB2-overexpressing cells. Taken together, this study shows that in human breast cancer cells, ErbB2 promotes glycolysis at least partially through the HSF1-mediated upregulation of LDH-A. This pathway may have a major role in regulating glucose metabolism in breast cancer cells. These novel findings have important implications for the design of new approaches to target ErbB2-overexpressing breast cancers."xsd:string |
| http://purl.uniprot.org/citations/19668225 | http://purl.org/dc/terms/identifier | "doi:10.1038/onc.2009.229"xsd:string |
| http://purl.uniprot.org/citations/19668225 | http://purl.uniprot.org/core/author | "Ding Y."xsd:string |
| http://purl.uniprot.org/citations/19668225 | http://purl.uniprot.org/core/author | "Liu H."xsd:string |
| http://purl.uniprot.org/citations/19668225 | http://purl.uniprot.org/core/author | "Tan M."xsd:string |
| http://purl.uniprot.org/citations/19668225 | http://purl.uniprot.org/core/author | "Yu D."xsd:string |
| http://purl.uniprot.org/citations/19668225 | http://purl.uniprot.org/core/author | "Zhou M."xsd:string |
| http://purl.uniprot.org/citations/19668225 | http://purl.uniprot.org/core/author | "Zhao Y.H."xsd:string |
| http://purl.uniprot.org/citations/19668225 | http://purl.uniprot.org/core/author | "Fodstad O."xsd:string |
| http://purl.uniprot.org/citations/19668225 | http://purl.uniprot.org/core/author | "Khong H.T."xsd:string |
| http://purl.uniprot.org/citations/19668225 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19668225 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/19668225 | http://purl.uniprot.org/core/pages | "3689-3701"xsd:string |
| http://purl.uniprot.org/citations/19668225 | http://purl.uniprot.org/core/title | "Upregulation of lactate dehydrogenase A by ErbB2 through heat shock factor 1 promotes breast cancer cell glycolysis and growth."xsd:string |
| http://purl.uniprot.org/citations/19668225 | http://purl.uniprot.org/core/volume | "28"xsd:string |
| http://purl.uniprot.org/citations/19668225 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19668225 |
| http://purl.uniprot.org/citations/19668225 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19668225 |
| http://purl.uniprot.org/uniprot/#_A0A8A0Y2Q6-mappedCitation-19668225 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19668225 |
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| http://purl.uniprot.org/uniprot/#_E2I6F8-mappedCitation-19668225 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19668225 |
| http://purl.uniprot.org/uniprot/#_B3KNQ9-mappedCitation-19668225 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19668225 |
| http://purl.uniprot.org/uniprot/#_B4DTR1-mappedCitation-19668225 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19668225 |
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| http://purl.uniprot.org/uniprot/#_B3KWP0-mappedCitation-19668225 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19668225 |