| http://purl.uniprot.org/citations/19669160 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19669160 | http://www.w3.org/2000/01/rdf-schema#comment | "Dopamine, acting at the D1 family receptors (D1R) is critical for the functioning of the amygdala, including fear conditioning and cue-induced reinstatement of drug self administration. However, little is known about the different contributions of the two D1R subtypes, D(1) and D(5). We identified D(1)-immunoreactive patches in the primate that appear similar to the intercalated cell masses reported in the rodent; however, both receptors were present across the subdivisions of the primate amygdala including the basolateral amygdala (BLA). Using immunoelectron microscopy, we established that both receptors have widespread distributions in BLA. The D1R subtypes colocalize in dendritic spines and terminals, with D(1) predominant in spines and D(5) in terminals. Single-cell RT-PCR confirmed that individual BLA projection neurons express both D(1) and D(5) mRNA. The responses of primate BLA neurons to dopamine and D1R drugs were studied using in vitro slices. We found that responses were similar to those previously reported in rat BLA neurons and included a mixture of postsynaptic and presynaptic actions. We investigated the distribution of D1R in the rat BLA and found that there were similarities between the species, such as more prominent D(5) localization to presynaptic structures. The higher affinity of D(5) for dopamine suggests that presynaptic actions may predominate in the BLA at low levels of dopamine, while postsynaptic effects increase and dominate as dopaminergic drive increases. The results presented here suggest a complex action of dopamine on BLA circuitry that may evolve with different degrees of dopaminergic stimulation."xsd:string |
| http://purl.uniprot.org/citations/19669160 | http://purl.org/dc/terms/identifier | "doi:10.1007/s00429-009-0214-8"xsd:string |
| http://purl.uniprot.org/citations/19669160 | http://purl.uniprot.org/core/author | "Rainnie D.G."xsd:string |
| http://purl.uniprot.org/citations/19669160 | http://purl.uniprot.org/core/author | "Khan Z.U."xsd:string |
| http://purl.uniprot.org/citations/19669160 | http://purl.uniprot.org/core/author | "Hazra R."xsd:string |
| http://purl.uniprot.org/citations/19669160 | http://purl.uniprot.org/core/author | "Guo J.D."xsd:string |
| http://purl.uniprot.org/citations/19669160 | http://purl.uniprot.org/core/author | "Muly E.C."xsd:string |
| http://purl.uniprot.org/citations/19669160 | http://purl.uniprot.org/core/author | "Senyuz M."xsd:string |
| http://purl.uniprot.org/citations/19669160 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19669160 | http://purl.uniprot.org/core/name | "Brain Struct Funct"xsd:string |
| http://purl.uniprot.org/citations/19669160 | http://purl.uniprot.org/core/pages | "375-393"xsd:string |
| http://purl.uniprot.org/citations/19669160 | http://purl.uniprot.org/core/title | "Distribution of D1 and D5 dopamine receptors in the primate and rat basolateral amygdala."xsd:string |
| http://purl.uniprot.org/citations/19669160 | http://purl.uniprot.org/core/volume | "213"xsd:string |
| http://purl.uniprot.org/citations/19669160 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19669160 |
| http://purl.uniprot.org/citations/19669160 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19669160 |
| http://purl.uniprot.org/uniprot/#_A6IJT5-mappedCitation-19669160 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19669160 |
| http://purl.uniprot.org/uniprot/#_P25115-mappedCitation-19669160 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19669160 |
| http://purl.uniprot.org/uniprot/A6IJT5 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19669160 |
| http://purl.uniprot.org/uniprot/P25115 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19669160 |