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| http://purl.uniprot.org/citations/19675228 | http://www.w3.org/2000/01/rdf-schema#comment | "Chloride influx through GABA-gated chloride channels, the primary mechanism by which neural activity is inhibited in the adult mammalian brain, depends on chloride gradients established by the potassium chloride cotransporter KCC2. We used a genetic screen to identify genes important for inhibition of the hermaphrodite-specific motor neurons (HSNs) that stimulate Caenorhabditis elegans egg-laying behavior and discovered mutations in a potassium chloride cotransporter, kcc-2. Functional analysis indicates that, like mammalian KCCs, C. elegans KCC-2 transports chloride, is activated by hypotonic conditions, and is inhibited by the loop diuretic furosemide. KCC-2 appears to establish chloride gradients required for the inhibitory effects of GABA-gated and serotonin-gated chloride channels on C. elegans behavior. In the absence of KCC-2, chloride gradients appear to be altered in neurons and muscles such that normally inhibitory signals become excitatory. kcc-2 is transcriptionally upregulated in the HSN neurons during synapse development. Loss of KCC-2 produces a decrease in the synaptic vesicle population within mature HSN synapses, which apparently compensates for a lack of HSN inhibition, resulting in normal egg-laying behavior. Thus, KCC-2 coordinates the development of inhibitory neurotransmission with synapse maturation to produce mature neural circuits with appropriate activity levels."xsd:string |
| http://purl.uniprot.org/citations/19675228 | http://purl.org/dc/terms/identifier | "doi:10.1523/jneurosci.1989-09.2009"xsd:string |
| http://purl.uniprot.org/citations/19675228 | http://purl.uniprot.org/core/author | "Moresco J.J."xsd:string |
| http://purl.uniprot.org/citations/19675228 | http://purl.uniprot.org/core/author | "Koelle M.R."xsd:string |
| http://purl.uniprot.org/citations/19675228 | http://purl.uniprot.org/core/author | "Tanis J.E."xsd:string |
| http://purl.uniprot.org/citations/19675228 | http://purl.uniprot.org/core/author | "Forbush B."xsd:string |
| http://purl.uniprot.org/citations/19675228 | http://purl.uniprot.org/core/author | "Bellemer A."xsd:string |
| http://purl.uniprot.org/citations/19675228 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19675228 | http://purl.uniprot.org/core/name | "J Neurosci"xsd:string |
| http://purl.uniprot.org/citations/19675228 | http://purl.uniprot.org/core/pages | "9943-9954"xsd:string |
| http://purl.uniprot.org/citations/19675228 | http://purl.uniprot.org/core/title | "The potassium chloride cotransporter KCC-2 coordinates development of inhibitory neurotransmission and synapse structure in Caenorhabditis elegans."xsd:string |
| http://purl.uniprot.org/citations/19675228 | http://purl.uniprot.org/core/volume | "29"xsd:string |
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