| http://purl.uniprot.org/citations/19675284 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19675284 | http://www.w3.org/2000/01/rdf-schema#comment | "Mast cells have been shown to play a role in development and persistence of various inflammatory bladder disorders. Mast cell-derived tryptase specifically activates protease-activated receptor-2 (PAR-2), and PAR-2 is known to be involved in inflammation. We investigated whether mast cells participate in increase of cyclooxygenase-2 (COX-2) protein abundance in urothelium/suburothelium of bladders of mice subsequent to cyclophosphamide (CYP)-induced bladder inflammation. We also used primary cultures of human urothelial cells to investigate cellular mechanisms underlying activation of PAR-2 resulting in increased COX-2 expression. We found that treatment of mice with CYP (150 mg/kg ip) increased COX-2 protein abundance in bladder urothelium/suburothelium 3, 6, and 24 h after CYP (P < 0.01), and increased COX-2 protein abundance was prevented by treatment of mice with the mast cell stabilizer sodium cromolyn (10 mg/kg ip) for 4 consecutive days before CYP treatment. Incubation of freshly isolated mouse urothelium/suburothelium with a selective PAR-2 agonist, 2-furoyl-LIGRLO-amide (3 microM), also increased COX-2 protein abundance (P < 0.05). We further demonstrated that 2-furoyl-LIGRLO-amide (3 microM) increased COX-2 mRNA expression and protein abundance in primary cultures of human urothelial cells (P < 0.01), and the effects of PAR-2 activation were mediated primarily by the ERK1/2 MAP kinase pathway. These data indicate that there are functional interactions among mast cells, PAR-2 activation, and increased expression of COX-2 in bladder inflammation."xsd:string |
| http://purl.uniprot.org/citations/19675284 | http://purl.org/dc/terms/identifier | "doi:10.1152/ajpregu.00310.2009"xsd:string |
| http://purl.uniprot.org/citations/19675284 | http://purl.uniprot.org/core/author | "Wang P."xsd:string |
| http://purl.uniprot.org/citations/19675284 | http://purl.uniprot.org/core/author | "Wang Z.Y."xsd:string |
| http://purl.uniprot.org/citations/19675284 | http://purl.uniprot.org/core/author | "Bjorling D.E."xsd:string |
| http://purl.uniprot.org/citations/19675284 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19675284 | http://purl.uniprot.org/core/name | "Am J Physiol Regul Integr Comp Physiol"xsd:string |
| http://purl.uniprot.org/citations/19675284 | http://purl.uniprot.org/core/pages | "R1127-35"xsd:string |
| http://purl.uniprot.org/citations/19675284 | http://purl.uniprot.org/core/title | "Role of mast cells and protease-activated receptor-2 in cyclooxygenase-2 expression in urothelial cells."xsd:string |
| http://purl.uniprot.org/citations/19675284 | http://purl.uniprot.org/core/volume | "297"xsd:string |
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