| http://purl.uniprot.org/citations/19680222 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19680222 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19680222 | http://www.w3.org/2000/01/rdf-schema#comment | "Greatwall (GW) is a new kinase that has an important function in the activation and the maintenance of cyclin B-Cdc2 activity. Although the mechanism by which it induces this effect is unknown, it has been suggested that GW could maintain cyclin B-Cdc2 activity by regulating its activation loop. Using Xenopus egg extracts, we show that GW depletion promotes mitotic exit, even in the presence of a high cyclin B-Cdc2 activity by inducing dephosphorylation of mitotic substrates. These results indicate that GW does not maintain the mitotic state by regulating the cyclin B-Cdc2 activation loop but by regulating a phosphatase. This phosphatase is PP2A; we show that (1) PP2A binds GW, (2) the inhibition or the specific depletion of this phosphatase from mitotic extracts rescues the phenotype induced by GW inactivation and (3) the PP2A-dependent dephosphorylation of cyclin B-Cdc2 substrates is increased in GW-depleted Xenopus egg extracts. These results suggest that mitotic entry and maintenance is not only mediated by the activation of cyclin B-Cdc2 but also by the regulation of PP2A by GW."xsd:string |
| http://purl.uniprot.org/citations/19680222 | http://purl.org/dc/terms/identifier | "doi:10.1038/emboj.2009.228"xsd:string |
| http://purl.uniprot.org/citations/19680222 | http://purl.org/dc/terms/identifier | "doi:10.1038/emboj.2009.228"xsd:string |
| http://purl.uniprot.org/citations/19680222 | http://purl.uniprot.org/core/author | "Labbe J.C."xsd:string |
| http://purl.uniprot.org/citations/19680222 | http://purl.uniprot.org/core/author | "Labbe J.C."xsd:string |
| http://purl.uniprot.org/citations/19680222 | http://purl.uniprot.org/core/author | "Brioudes E."xsd:string |
| http://purl.uniprot.org/citations/19680222 | http://purl.uniprot.org/core/author | "Brioudes E."xsd:string |
| http://purl.uniprot.org/citations/19680222 | http://purl.uniprot.org/core/author | "Burgess A."xsd:string |
| http://purl.uniprot.org/citations/19680222 | http://purl.uniprot.org/core/author | "Burgess A."xsd:string |
| http://purl.uniprot.org/citations/19680222 | http://purl.uniprot.org/core/author | "Castro A."xsd:string |
| http://purl.uniprot.org/citations/19680222 | http://purl.uniprot.org/core/author | "Castro A."xsd:string |
| http://purl.uniprot.org/citations/19680222 | http://purl.uniprot.org/core/author | "Lorca T."xsd:string |
| http://purl.uniprot.org/citations/19680222 | http://purl.uniprot.org/core/author | "Lorca T."xsd:string |
| http://purl.uniprot.org/citations/19680222 | http://purl.uniprot.org/core/author | "Vigneron S."xsd:string |
| http://purl.uniprot.org/citations/19680222 | http://purl.uniprot.org/core/author | "Vigneron S."xsd:string |
| http://purl.uniprot.org/citations/19680222 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19680222 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19680222 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/19680222 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/19680222 | http://purl.uniprot.org/core/pages | "2786-2793"xsd:string |
| http://purl.uniprot.org/citations/19680222 | http://purl.uniprot.org/core/pages | "2786-2793"xsd:string |
| http://purl.uniprot.org/citations/19680222 | http://purl.uniprot.org/core/title | "Greatwall maintains mitosis through regulation of PP2A."xsd:string |
| http://purl.uniprot.org/citations/19680222 | http://purl.uniprot.org/core/title | "Greatwall maintains mitosis through regulation of PP2A."xsd:string |