| http://purl.uniprot.org/citations/19682488 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19682488 | http://www.w3.org/2000/01/rdf-schema#comment | "We have shown that Caenorhabditis elegans lacking the PCM-1 protein repair l-isoaspartyl methyltransferase are more sensitive to oxidative stress than wild-type nematodes. Exposure to the redox-cycling quinone juglone upon exit from dauer diapause results in defective egg-laying (Egl phenotype) in the pcm-1 mutants only. Treatment with paraquat, a redox-cycling dipyridyl, causes a more severe developmental delay at the second larval stage in pcm-1 mutants than in wild-type nematodes. Finally, exposure to homocysteine and homocysteine thiolactone, molecules that can induce oxidative stress via distinct mechanisms, results in a more pronounced delay in development at the first larval stage in pcm-1 mutants than in wild-type animals. Homocysteine treatment also induced the Egl phenotype in mutant but not wild-type nematodes. All of the effects of these agents were reversed upon addition of vitamin C, indicating that the developmental delay and egg-laying defects result from oxidative stress. Furthermore, we have demonstrated that a mutation in the gene encoding the insulin-like receptor DAF-2 suppresses the Egl phenotype in pcm-1 mutants treated with juglone. Our results support a role of PCM-1 in the cellular responses mediated by the DAF-2 insulin-like signaling pathway in C. elegans for optimal protection against oxidative stress."xsd:string |
| http://purl.uniprot.org/citations/19682488 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.mad.2009.08.002"xsd:string |
| http://purl.uniprot.org/citations/19682488 | http://purl.uniprot.org/core/author | "Clarke S.G."xsd:string |
| http://purl.uniprot.org/citations/19682488 | http://purl.uniprot.org/core/author | "Gomez T."xsd:string |
| http://purl.uniprot.org/citations/19682488 | http://purl.uniprot.org/core/author | "Khare S."xsd:string |
| http://purl.uniprot.org/citations/19682488 | http://purl.uniprot.org/core/author | "Linster C.L."xsd:string |
| http://purl.uniprot.org/citations/19682488 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19682488 | http://purl.uniprot.org/core/name | "Mech Ageing Dev"xsd:string |
| http://purl.uniprot.org/citations/19682488 | http://purl.uniprot.org/core/pages | "670-680"xsd:string |
| http://purl.uniprot.org/citations/19682488 | http://purl.uniprot.org/core/title | "Defective responses to oxidative stress in protein l-isoaspartyl repair-deficient Caenorhabditis elegans."xsd:string |
| http://purl.uniprot.org/citations/19682488 | http://purl.uniprot.org/core/volume | "130"xsd:string |
| http://purl.uniprot.org/citations/19682488 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19682488 |
| http://purl.uniprot.org/citations/19682488 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19682488 |
| http://purl.uniprot.org/uniprot/#_G8JY24-mappedCitation-19682488 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19682488 |
| http://purl.uniprot.org/uniprot/#_Q5ZR76-mappedCitation-19682488 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19682488 |
| http://purl.uniprot.org/uniprot/#_Q27873-mappedCitation-19682488 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19682488 |
| http://purl.uniprot.org/uniprot/Q5ZR76 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19682488 |
| http://purl.uniprot.org/uniprot/G8JY24 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19682488 |
| http://purl.uniprot.org/uniprot/Q27873 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19682488 |