| http://purl.uniprot.org/citations/19684603 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19684603 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19684603 | http://www.w3.org/2000/01/rdf-schema#comment | "Using the Affymetrix 500K Mapping array and publicly available genotypes, we identified 18 SNPs whose allele frequency differed significantly(P < 1 x 10(-5)) between pediatric acute lymphoblastic leukemia (ALL) cases (n = 317) and non-ALL controls (n = 17,958). Two SNPs in ARID5B not only differed between ALL and non-ALL groups (rs10821936, P = 1.4 x 10(-15), odds ratio (OR) = 1.91; rs10994982, P = 5.7 x 10(-9), OR = 1.62) but also distinguished B-hyperdiploid ALL from other subtypes (rs10821936, P = 1.62 x 10(-5), OR = 2.17; rs10994982, P = 0.003, OR 1.72). These ARID5B SNPs also distinguished B-hyperdiploid ALL from other subtypes in an independent validation cohort (n = 124 children with ALL; P = 0.003 and P = 0.0008, OR 2.45 and 2.86, respectively) and were associated with methotrexate accumulation and gene expression pattern in leukemic lymphoblasts. We conclude that germline variants affect susceptibility to, and characteristics of, specific ALL subtypes."xsd:string |
| http://purl.uniprot.org/citations/19684603 | http://purl.org/dc/terms/identifier | "doi:10.1038/ng.432"xsd:string |
| http://purl.uniprot.org/citations/19684603 | http://purl.org/dc/terms/identifier | "doi:10.1038/ng.432"xsd:string |
| http://purl.uniprot.org/citations/19684603 | http://purl.uniprot.org/core/author | "Yang W."xsd:string |
| http://purl.uniprot.org/citations/19684603 | http://purl.uniprot.org/core/author | "Yang W."xsd:string |
| http://purl.uniprot.org/citations/19684603 | http://purl.uniprot.org/core/author | "Neale G."xsd:string |
| http://purl.uniprot.org/citations/19684603 | http://purl.uniprot.org/core/author | "Neale G."xsd:string |
| http://purl.uniprot.org/citations/19684603 | http://purl.uniprot.org/core/author | "Carroll W.L."xsd:string |
| http://purl.uniprot.org/citations/19684603 | http://purl.uniprot.org/core/author | "Carroll W.L."xsd:string |
| http://purl.uniprot.org/citations/19684603 | http://purl.uniprot.org/core/author | "Devidas M."xsd:string |
| http://purl.uniprot.org/citations/19684603 | http://purl.uniprot.org/core/author | "Devidas M."xsd:string |
| http://purl.uniprot.org/citations/19684603 | http://purl.uniprot.org/core/author | "Downing J."xsd:string |
| http://purl.uniprot.org/citations/19684603 | http://purl.uniprot.org/core/author | "Downing J."xsd:string |
| http://purl.uniprot.org/citations/19684603 | http://purl.uniprot.org/core/author | "Evans W.E."xsd:string |
| http://purl.uniprot.org/citations/19684603 | http://purl.uniprot.org/core/author | "Evans W.E."xsd:string |
| http://purl.uniprot.org/citations/19684603 | http://purl.uniprot.org/core/author | "French D."xsd:string |
| http://purl.uniprot.org/citations/19684603 | http://purl.uniprot.org/core/author | "French D."xsd:string |
| http://purl.uniprot.org/citations/19684603 | http://purl.uniprot.org/core/author | "Hunger S.P."xsd:string |
| http://purl.uniprot.org/citations/19684603 | http://purl.uniprot.org/core/author | "Hunger S.P."xsd:string |
| http://purl.uniprot.org/citations/19684603 | http://purl.uniprot.org/core/author | "Pui C.H."xsd:string |
| http://purl.uniprot.org/citations/19684603 | http://purl.uniprot.org/core/author | "Pui C.H."xsd:string |
| http://purl.uniprot.org/citations/19684603 | http://purl.uniprot.org/core/author | "Raimondi S.C."xsd:string |
| http://purl.uniprot.org/citations/19684603 | http://purl.uniprot.org/core/author | "Raimondi S.C."xsd:string |