| http://purl.uniprot.org/citations/19686689 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19686689 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19686689 | http://www.w3.org/2000/01/rdf-schema#comment | "Patterning of the primitive foregut promotes appropriate organ specification along its anterior-posterior axis. However, the molecular pathways specifying foregut endoderm progenitors are poorly understood. We show here that Wnt2/2b signaling is required to specify lung endoderm progenitors within the anterior foregut. Embryos lacking Wnt2/2b expression exhibit complete lung agenesis and do not express Nkx2.1, the earliest marker of the lung endoderm. In contrast, other foregut endoderm-derived organs, including the thyroid, liver, and pancreas, are correctly specified. The phenotype observed is recapitulated by an endoderm-restricted deletion of beta-catenin, demonstrating that Wnt2/2b signaling through the canonical Wnt pathway is required to specify lung endoderm progenitors within the foregut. Moreover, activation of canonical Wnt/beta-catenin signaling results in the reprogramming of esophagus and stomach endoderm to a lung endoderm progenitor fate. Together, these data reveal that canonical Wnt2/2b signaling is required for the specification of lung endoderm progenitors in the developing foregut."xsd:string |
| http://purl.uniprot.org/citations/19686689 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.devcel.2009.06.005"xsd:string |
| http://purl.uniprot.org/citations/19686689 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.devcel.2009.06.005"xsd:string |
| http://purl.uniprot.org/citations/19686689 | http://purl.uniprot.org/core/author | "Tian Y."xsd:string |
| http://purl.uniprot.org/citations/19686689 | http://purl.uniprot.org/core/author | "Tian Y."xsd:string |
| http://purl.uniprot.org/citations/19686689 | http://purl.uniprot.org/core/author | "Tsukiyama T."xsd:string |
| http://purl.uniprot.org/citations/19686689 | http://purl.uniprot.org/core/author | "Tsukiyama T."xsd:string |
| http://purl.uniprot.org/citations/19686689 | http://purl.uniprot.org/core/author | "Zhou D."xsd:string |
| http://purl.uniprot.org/citations/19686689 | http://purl.uniprot.org/core/author | "Zhou D."xsd:string |
| http://purl.uniprot.org/citations/19686689 | http://purl.uniprot.org/core/author | "Lu M.M."xsd:string |
| http://purl.uniprot.org/citations/19686689 | http://purl.uniprot.org/core/author | "Lu M.M."xsd:string |
| http://purl.uniprot.org/citations/19686689 | http://purl.uniprot.org/core/author | "Morrisey E.E."xsd:string |
| http://purl.uniprot.org/citations/19686689 | http://purl.uniprot.org/core/author | "Morrisey E.E."xsd:string |
| http://purl.uniprot.org/citations/19686689 | http://purl.uniprot.org/core/author | "Cohen E.D."xsd:string |
| http://purl.uniprot.org/citations/19686689 | http://purl.uniprot.org/core/author | "Cohen E.D."xsd:string |
| http://purl.uniprot.org/citations/19686689 | http://purl.uniprot.org/core/author | "Yamaguchi T.P."xsd:string |
| http://purl.uniprot.org/citations/19686689 | http://purl.uniprot.org/core/author | "Yamaguchi T.P."xsd:string |
| http://purl.uniprot.org/citations/19686689 | http://purl.uniprot.org/core/author | "Goss A.M."xsd:string |
| http://purl.uniprot.org/citations/19686689 | http://purl.uniprot.org/core/author | "Goss A.M."xsd:string |
| http://purl.uniprot.org/citations/19686689 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19686689 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19686689 | http://purl.uniprot.org/core/name | "Dev. Cell"xsd:string |
| http://purl.uniprot.org/citations/19686689 | http://purl.uniprot.org/core/name | "Dev. Cell"xsd:string |