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Background

Serum magnesium concentration is a quantitative trait with substantial heritability. Although the pool of candidate genes continues to grow, only the histocompatibility locus has been associated with magnesium levels. To explore other possibilities, we targeted 6 candidate genes physiologically relevant to magnesium metabolism.

Methods

We studied a large cohort (n=471) derived from a well-characterized population of healthy Caucasian women 18 to 35 years. Total serum magnesium and calcium were measured by atomic absorption spectrophotometry (aaMg & aaCa). Genomic DNA was amplified and SNPs in candidate genes (CASR, VDR, ESR1, CLDN16, EGF1, TRPM6) genotyped by routine methods.

Results

We found a significant association between estrogen receptor alpha (ESR1) polymorphisms, PvuII and XbaI, and magnesium (r=-0.116, p=0.012 and r=-0.126, p=0.006, respectively). Stratifying by PvuII genotype (P/p alleles), the mean adjusted total magnesium (aaMg) concentration was significantly higher (p=0.01) in the pp group (0.823+/-0.005 mmol/l, n=130) than in PP homozygotes (0.805+/-0.006 mmol/l, n=70), and the mean in Pp heterozygotes was intermediate (0.810+/-0.005 mmol/l, n=180). No significant associations were observed with the other candidate genes tested.

Conclusions

The significant association between magnesium and ESR1 polymorphisms supports previous studies linking physiologic changes in serum magnesium to estrogen status."xsd:string
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http://purl.uniprot.org/citations/19695239http://purl.uniprot.org/core/author"Liu Z."xsd:string
http://purl.uniprot.org/citations/19695239http://purl.uniprot.org/core/author"Li M."xsd:string
http://purl.uniprot.org/citations/19695239http://purl.uniprot.org/core/author"Wei C."xsd:string
http://purl.uniprot.org/citations/19695239http://purl.uniprot.org/core/author"Cole D.E."xsd:string
http://purl.uniprot.org/citations/19695239http://purl.uniprot.org/core/author"Shuen A.Y."xsd:string
http://purl.uniprot.org/citations/19695239http://purl.uniprot.org/core/author"Wong B.Y."xsd:string
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http://purl.uniprot.org/citations/19695239http://purl.uniprot.org/core/name"Clin Chim Acta"xsd:string
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http://purl.uniprot.org/citations/19695239http://purl.uniprot.org/core/title"Genetic determinants of extracellular magnesium concentration: analysis of multiple candidate genes, and evidence for association with the estrogen receptor alpha (ESR1) locus."xsd:string
http://purl.uniprot.org/citations/19695239http://purl.uniprot.org/core/volume"409"xsd:string
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