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| http://purl.uniprot.org/citations/19695344 | http://www.w3.org/2000/01/rdf-schema#comment | "Drosophila melanogaster larval neuromuscular junctions (NMJs) serve as a model for synaptic physiology. The molecular sequences of the postsynaptic glutamate receptors have been described; however, the pharmacological profile has not been fully elucidated. The postsynaptic molecular sequence suggests a novel glutamate receptor subtype. Kainate does not depolarize the muscle, but dampens evoked EPSP amplitudes. Quantal responses show a decreased amplitude and area under the voltage curve indicative of reduced postsynaptic receptor sensitivity to glutamate transmission. ATPA, a kainate receptor agonist, did not mimic kainate's action. The metabotropic glutamate receptor agonist t-ACPD had no effect. Domoic acid, a kainate/AMPA receptor agonist, blocks the postsynaptic receptors without depolarizing the muscle. However, SYM 2081, a kainate receptor agonist, did depolarize the muscle and reduce the EPSP amplitude at 1 mM but not at 0.1 mM. This supports the notion that these are generally a quisqualate subtype receptors with some oddities in the pharmacological profile. The results suggest a direct postsynaptic action of kainate due to partial antagonist action on the quisqualate receptors. There does not appear to be presynaptic auto-regulation via a kainate receptor subtype or a metabotropic auto-receptor. This study aids in furthering the pharmokinetic profiling and specificity of the receptor subtypes."xsd:string |
| http://purl.uniprot.org/citations/19695344 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cbpc.2009.08.002"xsd:string |
| http://purl.uniprot.org/citations/19695344 | http://purl.uniprot.org/core/author | "Lee J.Y."xsd:string |
| http://purl.uniprot.org/citations/19695344 | http://purl.uniprot.org/core/author | "Bhatt D."xsd:string |
| http://purl.uniprot.org/citations/19695344 | http://purl.uniprot.org/core/author | "Chung W.Y."xsd:string |
| http://purl.uniprot.org/citations/19695344 | http://purl.uniprot.org/core/author | "Cooper R.L."xsd:string |
| http://purl.uniprot.org/citations/19695344 | http://purl.uniprot.org/core/author | "Bhatt D.'"xsd:string |
| http://purl.uniprot.org/citations/19695344 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19695344 | http://purl.uniprot.org/core/name | "Comp Biochem Physiol C Toxicol Pharmacol"xsd:string |
| http://purl.uniprot.org/citations/19695344 | http://purl.uniprot.org/core/pages | "546-557"xsd:string |
| http://purl.uniprot.org/citations/19695344 | http://purl.uniprot.org/core/title | "Furthering pharmacological and physiological assessment of the glutamatergic receptors at the Drosophila neuromuscular junction."xsd:string |
| http://purl.uniprot.org/citations/19695344 | http://purl.uniprot.org/core/volume | "150"xsd:string |
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