| http://purl.uniprot.org/citations/19696028 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19696028 | http://www.w3.org/2000/01/rdf-schema#comment | "Microtubule plus-end tracking proteins (+TIPs) control microtubule dynamics in fundamental processes such as cell cycle, intracellular transport, and cell motility, but how +TIPs are regulated during mitosis remains largely unclear. Here we show that the endogenous end-binding protein family EB3 is stable during mitosis, facilitates cell cycle progression at prometaphase, and then is down-regulated during the transition to G(1) phase. The ubiquitin-protein isopeptide ligase SIAH-1 facilitates EB3 polyubiquitination and subsequent proteasome-mediated degradation, whereas SIAH-1 knockdown increases EB3 stability and steady-state levels. Two mitotic kinases, Aurora-A and Aurora-B, phosphorylate endogenous EB3 at Ser-176, and the phosphorylation triggers disruption of the EB3-SIAH-1 complex, resulting in EB3 stabilization during mitosis. Our results provide new insight into a regulatory mechanism of +TIPs in cell cycle transition."xsd:string |
| http://purl.uniprot.org/citations/19696028 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m109.000273"xsd:string |
| http://purl.uniprot.org/citations/19696028 | http://purl.uniprot.org/core/author | "Furukawa K."xsd:string |
| http://purl.uniprot.org/citations/19696028 | http://purl.uniprot.org/core/author | "Park S.Y."xsd:string |
| http://purl.uniprot.org/citations/19696028 | http://purl.uniprot.org/core/author | "Tanaka H."xsd:string |
| http://purl.uniprot.org/citations/19696028 | http://purl.uniprot.org/core/author | "Taniguchi H."xsd:string |
| http://purl.uniprot.org/citations/19696028 | http://purl.uniprot.org/core/author | "Urano T."xsd:string |
| http://purl.uniprot.org/citations/19696028 | http://purl.uniprot.org/core/author | "Akashi T."xsd:string |
| http://purl.uniprot.org/citations/19696028 | http://purl.uniprot.org/core/author | "Matsuzaki H."xsd:string |
| http://purl.uniprot.org/citations/19696028 | http://purl.uniprot.org/core/author | "Sakashita G."xsd:string |
| http://purl.uniprot.org/citations/19696028 | http://purl.uniprot.org/core/author | "Ban R."xsd:string |
| http://purl.uniprot.org/citations/19696028 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19696028 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/19696028 | http://purl.uniprot.org/core/pages | "28367-28381"xsd:string |
| http://purl.uniprot.org/citations/19696028 | http://purl.uniprot.org/core/title | "Mitotic regulation of the stability of microtubule plus-end tracking protein EB3 by ubiquitin ligase SIAH-1 and Aurora mitotic kinases."xsd:string |
| http://purl.uniprot.org/citations/19696028 | http://purl.uniprot.org/core/volume | "284"xsd:string |
| http://purl.uniprot.org/citations/19696028 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19696028 |
| http://purl.uniprot.org/citations/19696028 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19696028 |
| http://purl.uniprot.org/uniprot/#_B2R5W6-mappedCitation-19696028 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19696028 |
| http://purl.uniprot.org/uniprot/#_B2RC06-mappedCitation-19696028 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19696028 |
| http://purl.uniprot.org/uniprot/#_B2R6Z3-mappedCitation-19696028 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19696028 |
| http://purl.uniprot.org/uniprot/#_B4DX16-mappedCitation-19696028 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19696028 |
| http://purl.uniprot.org/uniprot/#_B7Z867-mappedCitation-19696028 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19696028 |
| http://purl.uniprot.org/uniprot/#_O14965-mappedCitation-19696028 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19696028 |