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http://purl.uniprot.org/citations/19696402http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/19696402http://www.w3.org/2000/01/rdf-schema#comment"

Objective

The purpose of this study was to determine the effect of a variant in EPCR (Ser219Gly), previously shown to affect EPCR shedding, on plasma FVII, FVIIa, and downstream markers of activated coagulation.

Methods and results

Statistical analysis was undertaken in approximately 2000 healthy middle aged men (NPHSII). Higher soluble EPCR levels were confirmed for Gly allele carriers (P<0.0001). Significantly higher levels of FVII, FVIIa, and downstream markers of activated coagulation in the extrinsic pathway (FIX activation pep [FIXpep]; FX activation pep [FXpep]), and prothrombin F1+2 (F1+2) were identified in baseline samples, in Gly carriers compared to Ser/Ser (PConclusionsThese data suggest that higher levels of FVII and FVIIa circulate when EPCR shedding is greatest. Furthermore, these results suggest consequences for activation of extrinsic coagulation."xsd:string
http://purl.uniprot.org/citations/19696402http://purl.org/dc/terms/identifier"doi:10.1161/atvbaha.109.191551"xsd:string
http://purl.uniprot.org/citations/19696402http://purl.uniprot.org/core/author"Cooper J.A."xsd:string
http://purl.uniprot.org/citations/19696402http://purl.uniprot.org/core/author"Humphries S.E."xsd:string
http://purl.uniprot.org/citations/19696402http://purl.uniprot.org/core/author"Mitchell J.P."xsd:string
http://purl.uniprot.org/citations/19696402http://purl.uniprot.org/core/author"Bauer K.A."xsd:string
http://purl.uniprot.org/citations/19696402http://purl.uniprot.org/core/author"Ireland H.A."xsd:string
http://purl.uniprot.org/citations/19696402http://purl.uniprot.org/core/author"Morrissey J.H."xsd:string
http://purl.uniprot.org/citations/19696402http://purl.uniprot.org/core/author"Acharya J."xsd:string
http://purl.uniprot.org/citations/19696402http://purl.uniprot.org/core/author"Drenos F."xsd:string
http://purl.uniprot.org/citations/19696402http://purl.uniprot.org/core/author"Esnouf M.P."xsd:string
http://purl.uniprot.org/citations/19696402http://purl.uniprot.org/core/date"2009"xsd:gYear
http://purl.uniprot.org/citations/19696402http://purl.uniprot.org/core/name"Arterioscler Thromb Vasc Biol"xsd:string
http://purl.uniprot.org/citations/19696402http://purl.uniprot.org/core/pages"1968-1974"xsd:string
http://purl.uniprot.org/citations/19696402http://purl.uniprot.org/core/title"FVII, FVIIa, and downstream markers of extrinsic pathway activation differ by EPCR Ser219Gly variant in healthy men."xsd:string
http://purl.uniprot.org/citations/19696402http://purl.uniprot.org/core/volume"29"xsd:string
http://purl.uniprot.org/citations/19696402http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/19696402
http://purl.uniprot.org/citations/19696402http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/19696402
http://purl.uniprot.org/uniprot/Q9UNN8#attribution-DB1D18A648EAD2AC1CE88EC7D713D99Bhttp://purl.uniprot.org/core/sourcehttp://purl.uniprot.org/citations/19696402
http://purl.uniprot.org/uniprot/#_Q9UNN8-mappedCitation-19696402http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/19696402
http://purl.uniprot.org/uniprot/Q9UNN8http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/19696402