| http://purl.uniprot.org/citations/19696636 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19696636 | http://www.w3.org/2000/01/rdf-schema#comment | "BackgroundHematopoietic stem-cell transplantation is a well-established treatment in various hematologic malignancies, but the outcome depends on disease relapse, infections, and the development and severity of acute and chronic graft-versus-host disease. Some evidence has revealed an important role for the nonclassical major histocompatibility complex class I molecules in transplantation, most notably human leukocyte antigen (HLA)-E. This study evaluates the impact of HLA-E alleles on transplantation outcome after HLA-matched allogeneic HSCT.MethodsWe genotyped DNA for HLA-E polymorphism from 83 recipients and their respective donors by real-time polymerase chain reaction after melting curve analysis and compared the results with clinical outcome.ResultsHLA-E*0103 homozygous patients showed a higher probability of overall survival (P=0.003) and disease-free survival (P=0.001) in a univariate model. Cox regression analysis confirmed HLA-E*0103, 0103 (P=0.006; relative risk 1.12; 95% confidence interval 0.31-1.94) and early stage of disease (P=0.005; relative risk 1.16; 95% confidence interval 0.45-1.86) as independent factors improving overall survival. Moreover, homozygosity for HLA-E*0103 was associated with a significant decreased incidence of transplant-related mortality (P=0.01).ConclusionsWe found an association between HLA-E*0103 homozygosity and the significant reduction of transplant-related mortality in related and unrelated HSCT. The risk of posttransplant complications was significantly reduced when the donor possesses the HLA-E*0103, 0103 genotype, and this was translated in a better overall survival."xsd:string |
| http://purl.uniprot.org/citations/19696636 | http://purl.org/dc/terms/identifier | "doi:10.1097/tp.0b013e3181b0e79e"xsd:string |
| http://purl.uniprot.org/citations/19696636 | http://purl.uniprot.org/core/author | "Hauser H."xsd:string |
| http://purl.uniprot.org/citations/19696636 | http://purl.uniprot.org/core/author | "Binder M."xsd:string |
| http://purl.uniprot.org/citations/19696636 | http://purl.uniprot.org/core/author | "Weiss R."xsd:string |
| http://purl.uniprot.org/citations/19696636 | http://purl.uniprot.org/core/author | "Konig J."xsd:string |
| http://purl.uniprot.org/citations/19696636 | http://purl.uniprot.org/core/author | "Gabriel C."xsd:string |
| http://purl.uniprot.org/citations/19696636 | http://purl.uniprot.org/core/author | "Krieger O."xsd:string |
| http://purl.uniprot.org/citations/19696636 | http://purl.uniprot.org/core/author | "Danzer M."xsd:string |
| http://purl.uniprot.org/citations/19696636 | http://purl.uniprot.org/core/author | "Hofer K."xsd:string |
| http://purl.uniprot.org/citations/19696636 | http://purl.uniprot.org/core/author | "Polin H."xsd:string |
| http://purl.uniprot.org/citations/19696636 | http://purl.uniprot.org/core/author | "Proll J."xsd:string |
| http://purl.uniprot.org/citations/19696636 | http://purl.uniprot.org/core/author | "Haunschmid R."xsd:string |
| http://purl.uniprot.org/citations/19696636 | http://purl.uniprot.org/core/author | "Stabentheiner S."xsd:string |
| http://purl.uniprot.org/citations/19696636 | http://purl.uniprot.org/core/author | "Hackl C."xsd:string |
| http://purl.uniprot.org/citations/19696636 | http://purl.uniprot.org/core/author | "Kasparu H."xsd:string |
| http://purl.uniprot.org/citations/19696636 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19696636 | http://purl.uniprot.org/core/name | "Transplantation"xsd:string |
| http://purl.uniprot.org/citations/19696636 | http://purl.uniprot.org/core/pages | "528-532"xsd:string |
| http://purl.uniprot.org/citations/19696636 | http://purl.uniprot.org/core/title | "Clinical significance of HLA-E*0103 homozygosity on survival after allogeneic hematopoietic stem-cell transplantation."xsd:string |
| http://purl.uniprot.org/citations/19696636 | http://purl.uniprot.org/core/volume | "88"xsd:string |
| http://purl.uniprot.org/citations/19696636 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19696636 |
| http://purl.uniprot.org/citations/19696636 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19696636 |
| http://purl.uniprot.org/uniprot/#_A0A0F7WBW2-mappedCitation-19696636 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19696636 |