| http://purl.uniprot.org/citations/19696787 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19696787 | http://www.w3.org/2000/01/rdf-schema#comment | "Aberrant oncogene activation induces cellular senescence, an irreversible growth arrest that acts as a barrier against tumorigenesis. To identify microRNAs (miRNAs) involved in oncogene-induced senescence, we examined the expression of miRNAs in primary human TIG3 fibroblasts after constitutive activation of B-RAF. Among the regulated miRNAs, both miR-34a and miR-146a were strongly induced during senescence. Although members of the miR-34 family are known to be transcriptionally regulated by p53, we find that miR-34a is regulated independently of p53 during oncogene-induced senescence. Instead, upregulation of miR-34a is mediated by the ETS family transcription factor, ELK1. During senescence, miR-34a targets the important proto-oncogene MYC and our data suggest that miR-34a thereby coordinately controls a set of cell cycle regulators. Hence, in addition to its integration in the p53 pathway, we show that alternative cancer-related pathways regulate miR-34a, emphasising its significance as a tumour suppressor."xsd:string |
| http://purl.uniprot.org/citations/19696787 | http://purl.org/dc/terms/identifier | "doi:10.1038/cdd.2009.109"xsd:string |
| http://purl.uniprot.org/citations/19696787 | http://purl.uniprot.org/core/author | "Oren M."xsd:string |
| http://purl.uniprot.org/citations/19696787 | http://purl.uniprot.org/core/author | "Nielsen F.C."xsd:string |
| http://purl.uniprot.org/citations/19696787 | http://purl.uniprot.org/core/author | "Pilpel Y."xsd:string |
| http://purl.uniprot.org/citations/19696787 | http://purl.uniprot.org/core/author | "Lund A.H."xsd:string |
| http://purl.uniprot.org/citations/19696787 | http://purl.uniprot.org/core/author | "Lees M."xsd:string |
| http://purl.uniprot.org/citations/19696787 | http://purl.uniprot.org/core/author | "Frankel L.B."xsd:string |
| http://purl.uniprot.org/citations/19696787 | http://purl.uniprot.org/core/author | "Shalgi R."xsd:string |
| http://purl.uniprot.org/citations/19696787 | http://purl.uniprot.org/core/author | "Klausen M."xsd:string |
| http://purl.uniprot.org/citations/19696787 | http://purl.uniprot.org/core/author | "Christoffersen N.R."xsd:string |
| http://purl.uniprot.org/citations/19696787 | http://purl.uniprot.org/core/author | "Leucci E."xsd:string |
| http://purl.uniprot.org/citations/19696787 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/19696787 | http://purl.uniprot.org/core/name | "Cell Death Differ"xsd:string |
| http://purl.uniprot.org/citations/19696787 | http://purl.uniprot.org/core/pages | "236-245"xsd:string |
| http://purl.uniprot.org/citations/19696787 | http://purl.uniprot.org/core/title | "p53-independent upregulation of miR-34a during oncogene-induced senescence represses MYC."xsd:string |
| http://purl.uniprot.org/citations/19696787 | http://purl.uniprot.org/core/volume | "17"xsd:string |
| http://purl.uniprot.org/citations/19696787 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19696787 |
| http://purl.uniprot.org/citations/19696787 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19696787 |
| http://purl.uniprot.org/uniprot/#_A0A0B4J1R1-mappedCitation-19696787 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19696787 |
| http://purl.uniprot.org/uniprot/#_A0N2G3-mappedCitation-19696787 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19696787 |
| http://purl.uniprot.org/uniprot/#_A0A224B085-mappedCitation-19696787 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19696787 |
| http://purl.uniprot.org/uniprot/#_B3CJ86-mappedCitation-19696787 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19696787 |
| http://purl.uniprot.org/uniprot/#_B3CJ87-mappedCitation-19696787 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19696787 |