| http://purl.uniprot.org/citations/19698125 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19698125 | http://www.w3.org/2000/01/rdf-schema#comment | "BackgroundMany epidemiological studies have shown that the genetic factors of the host play a role in the variability of clinical response to infection caused by M. leprae. With the purpose of identifying genes of susceptibility, the present study investigated the possible role of HLA-DRB1 and DQA1/DQB1 alleles in susceptibility to leprosy, and whether they account for the heterogeneity in immune responses observed following infection in a Southern Brazilian population.MethodsOne hundred and sixty-nine leprosy patients and 217 healthy controls were analyzed by polymerase chain reaction amplification and reverse hybridization with sequence-specific oligonucleotide probes and sequence-specific primers (One Lambda, CA, USA).ResultsThere was a positive association of HLA-DRB1*16 (*1601 and *1602) with leprosy per se (7.3% vs. 3.2%, P = 0.01, OR = 2.52, CI = 1.26-5.01), in accord with previous serological studies, which showed DR2 as a marker of leprosy. Although, HLA-DQA1*05 frequency (29.8% vs. 20.9%, P = 0.0424, OR = 1.61, CI = 1.09-2.39) was higher in patients, and HLA-DQA1*02 (3.0% vs. 7.5%, P = 0.0392, OR = 0.39, CI = 0.16 - 0.95) and HLA-DQA1*04 (4.0% vs. 9.1%, P = 0.0314, OR = 0.42, CI = 0.19 - 0.93) frequencies lower, P-values were not significant after the Bonferroni's correction. Furthermore, HLA-DRB1*1601 (9.0% vs. 1.8%; P = 0.0016; OR = 5.81; CI = 2.05-16.46) was associated with susceptibility to borderline leprosy compared to control group, and while HLA-DRB1*08 (11.2% vs. 1.2%; P = 0.0037; OR = 12.00; CI = 1.51 - 95.12) was associated with susceptibility to lepromatous leprosy, when compared to tuberculoid leprosy, DRB1*04 was associated to protection.ConclusionThese data confirm the positive association of HLA-DR2 (DRB1*16) with leprosy per se, and the protector effect of DRB1*04 against lepromatous leprosy in Brazilian patients."xsd:string |
| http://purl.uniprot.org/citations/19698125 | http://purl.org/dc/terms/identifier | "doi:10.1186/1471-2334-9-134"xsd:string |
| http://purl.uniprot.org/citations/19698125 | http://purl.uniprot.org/core/author | "Reis P.G."xsd:string |
| http://purl.uniprot.org/citations/19698125 | http://purl.uniprot.org/core/author | "da Silva S.A."xsd:string |
| http://purl.uniprot.org/citations/19698125 | http://purl.uniprot.org/core/author | "Tsuneto L.T."xsd:string |
| http://purl.uniprot.org/citations/19698125 | http://purl.uniprot.org/core/author | "Visentainer J.E."xsd:string |
| http://purl.uniprot.org/citations/19698125 | http://purl.uniprot.org/core/author | "Sell A.M."xsd:string |
| http://purl.uniprot.org/citations/19698125 | http://purl.uniprot.org/core/author | "Mazini P.S."xsd:string |
| http://purl.uniprot.org/citations/19698125 | http://purl.uniprot.org/core/author | "Peixoto P.R."xsd:string |
| http://purl.uniprot.org/citations/19698125 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19698125 | http://purl.uniprot.org/core/name | "BMC Infect Dis"xsd:string |
| http://purl.uniprot.org/citations/19698125 | http://purl.uniprot.org/core/pages | "134"xsd:string |
| http://purl.uniprot.org/citations/19698125 | http://purl.uniprot.org/core/title | "HLA-DR and HLA-DQ alleles in patients from the south of Brazil: markers for leprosy susceptibility and resistance."xsd:string |
| http://purl.uniprot.org/citations/19698125 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/19698125 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19698125 |
| http://purl.uniprot.org/citations/19698125 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19698125 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3H3-mappedCitation-19698125 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19698125 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3I1-mappedCitation-19698125 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19698125 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3I5-mappedCitation-19698125 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19698125 |
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| http://purl.uniprot.org/uniprot/#_A0A076L4M5-mappedCitation-19698125 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19698125 |
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| http://purl.uniprot.org/uniprot/#_A0A0A7C7I5-mappedCitation-19698125 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19698125 |