| http://purl.uniprot.org/citations/19698770 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19698770 | http://www.w3.org/2000/01/rdf-schema#comment | "Goniothalamin, a styryllactone, has been shown to induce cytotoxicity via apoptosis in several tumor cell lines. In this study, we have examined the potential role of several genes, which were stably transfected into T-cell lines and which regulate apoptosis in different ways, on goniothalamin-induced cell death. Overexpression of full-length receptor for activated protein C-kinase 1 (RACK-1) and pc3n3, which up-regulates endogenous RACK-1, in both Jurkat and W7.2 T cells resulted in inhibition of goniothalamin-induced cell death as assessed by MTT and clonogenic assays. However, overexpression of rFau (antisense sequence to Finkel-Biskis-Reilly murine sarcoma virus-associated ubiquitously expressed gene) in W7.2 cells did not confer resistance to goniothalamin-induced cell death. Etoposide, a clinically used cytotoxic agent, was equipotent in causing cytotoxicity in all the stable transfectants. Assessment of DNA damage by Comet assay revealed goniothalamin-induced DNA strand breaks as early as 1 h in vector control but this effect was inhibited in RACK-1 and pc3n3 stably transfected W7.2 cells. This data demonstrate that RACK-1 plays a crucial role in regulating cell death signalling pathways induced by goniothalamin."xsd:string |
| http://purl.uniprot.org/citations/19698770 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.toxlet.2009.08.012"xsd:string |
| http://purl.uniprot.org/citations/19698770 | http://purl.uniprot.org/core/author | "Chan K.M."xsd:string |
| http://purl.uniprot.org/citations/19698770 | http://purl.uniprot.org/core/author | "Farzaneh F."xsd:string |
| http://purl.uniprot.org/citations/19698770 | http://purl.uniprot.org/core/author | "Saxena N."xsd:string |
| http://purl.uniprot.org/citations/19698770 | http://purl.uniprot.org/core/author | "Mourtada-Maarabouni M."xsd:string |
| http://purl.uniprot.org/citations/19698770 | http://purl.uniprot.org/core/author | "Williams G.T."xsd:string |
| http://purl.uniprot.org/citations/19698770 | http://purl.uniprot.org/core/author | "Wong L.T."xsd:string |
| http://purl.uniprot.org/citations/19698770 | http://purl.uniprot.org/core/author | "Rajab N.F."xsd:string |
| http://purl.uniprot.org/citations/19698770 | http://purl.uniprot.org/core/author | "Inayat-Hussain S.H."xsd:string |
| http://purl.uniprot.org/citations/19698770 | http://purl.uniprot.org/core/author | "Harun R."xsd:string |
| http://purl.uniprot.org/citations/19698770 | http://purl.uniprot.org/core/author | "Din L.B."xsd:string |
| http://purl.uniprot.org/citations/19698770 | http://purl.uniprot.org/core/author | "Kizilors A."xsd:string |
| http://purl.uniprot.org/citations/19698770 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19698770 | http://purl.uniprot.org/core/name | "Toxicol Lett"xsd:string |
| http://purl.uniprot.org/citations/19698770 | http://purl.uniprot.org/core/pages | "118-122"xsd:string |
| http://purl.uniprot.org/citations/19698770 | http://purl.uniprot.org/core/title | "RACK-1 overexpression protects against goniothalamin-induced cell death."xsd:string |
| http://purl.uniprot.org/citations/19698770 | http://purl.uniprot.org/core/volume | "191"xsd:string |
| http://purl.uniprot.org/citations/19698770 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19698770 |
| http://purl.uniprot.org/citations/19698770 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19698770 |
| http://purl.uniprot.org/uniprot/#_P68040-mappedCitation-19698770 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19698770 |
| http://purl.uniprot.org/uniprot/P68040 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19698770 |