| http://purl.uniprot.org/citations/19698991 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19698991 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19698991 | http://www.w3.org/2000/01/rdf-schema#comment | "Tumor necrosis factor receptor-associated factor 1 (TRAF1) is unique among the members of the TRAF family, as it lacks the N-terminal RING/zinc-finger domain. Also the function of TRAF1 is not clearly established, with many papers reporting contradictory results. Here we show that TRAF1 interacts with BAFF receptor, a member of the TNF receptor family, and positively regulates activation of the alternative NF-kappaB pathway. Ectopic expression of TRAF1 causes degradation of TRAF3, stabilization of NIK, and processing of p100 to produce the mature form p52. In addition, we show that knocking-down expression of TRAF1 in the Hodgkin's disease derived cell line L1236, interfere with p100 processing and with p52 mediate gene transcription. Collectively these results support a role for TRAF1 as a positive regulator of the NF-kappaB alternative pathway."xsd:string |
| http://purl.uniprot.org/citations/19698991 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molimm.2009.07.029"xsd:string |
| http://purl.uniprot.org/citations/19698991 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molimm.2009.07.029"xsd:string |
| http://purl.uniprot.org/citations/19698991 | http://purl.uniprot.org/core/author | "Formisano S."xsd:string |
| http://purl.uniprot.org/citations/19698991 | http://purl.uniprot.org/core/author | "Formisano S."xsd:string |
| http://purl.uniprot.org/citations/19698991 | http://purl.uniprot.org/core/author | "Leonardi A."xsd:string |
| http://purl.uniprot.org/citations/19698991 | http://purl.uniprot.org/core/author | "Leonardi A."xsd:string |
| http://purl.uniprot.org/citations/19698991 | http://purl.uniprot.org/core/author | "Lavorgna A."xsd:string |
| http://purl.uniprot.org/citations/19698991 | http://purl.uniprot.org/core/author | "Lavorgna A."xsd:string |
| http://purl.uniprot.org/citations/19698991 | http://purl.uniprot.org/core/author | "De Filippi R."xsd:string |
| http://purl.uniprot.org/citations/19698991 | http://purl.uniprot.org/core/author | "De Filippi R."xsd:string |
| http://purl.uniprot.org/citations/19698991 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19698991 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19698991 | http://purl.uniprot.org/core/name | "Mol. Immunol."xsd:string |
| http://purl.uniprot.org/citations/19698991 | http://purl.uniprot.org/core/name | "Mol. Immunol."xsd:string |
| http://purl.uniprot.org/citations/19698991 | http://purl.uniprot.org/core/pages | "3278-3282"xsd:string |
| http://purl.uniprot.org/citations/19698991 | http://purl.uniprot.org/core/pages | "3278-3282"xsd:string |
| http://purl.uniprot.org/citations/19698991 | http://purl.uniprot.org/core/title | "TNF receptor-associated factor 1 is a positive regulator of the NF-kappaB alternative pathway."xsd:string |
| http://purl.uniprot.org/citations/19698991 | http://purl.uniprot.org/core/title | "TNF receptor-associated factor 1 is a positive regulator of the NF-kappaB alternative pathway."xsd:string |
| http://purl.uniprot.org/citations/19698991 | http://purl.uniprot.org/core/volume | "46"xsd:string |
| http://purl.uniprot.org/citations/19698991 | http://purl.uniprot.org/core/volume | "46"xsd:string |
| http://purl.uniprot.org/citations/19698991 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19698991 |
| http://purl.uniprot.org/citations/19698991 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19698991 |