| http://purl.uniprot.org/citations/19700760 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19700760 | http://www.w3.org/2000/01/rdf-schema#comment | "Carcinoembryonic antigen-related cellular adhesion molecule 1 (CEACAM1) is a CEA family member that has been reported to have an important role in the regulation of Th1-mediated colitis. In this study, we examined the role of CEACAM1 in an animal model of multiple sclerosis, experimental autoimmune encephalomyelitis (EAE). Treatment of C57BL/6J mice with CEACAM1-Fc fusion protein, a homophilic ligand of CEACAM1, inhibited the severity of EAE and reduced myelin oligodendrocyte glycoprotein-derived peptide (MOG(35-55))-reactive interferon-gamma and interleukin-17 production. In contrast, treatment of these animals with AgB10, an anti-mouse CEACAM1 blocking monoclonal antibody, generated increased severity of EAE in association with increased MOG(35-55)-specific induction of both interferon-gamma and interleukin-17. These results indicated that the signal elicited through CEACAM1 ameliorated EAE disease severity. Furthermore, we found that there was both a rapid and enhanced expression of CEACAM1 on invariant natural killer T cells after activation. The effect of CEACAM1-Fc fusion protein and anti-CEACAM1 mAb on both EAE and MOG(35-55)-reactive cytokine responses were abolished in invariant natural killer T cell-deficient Jalpha18(-/-) mice. Taken together, the ligation of CEACAM1 negatively regulates the severity of EAE by reducing MOG(35-55)-specific induction of both interferon-gamma and interleukin-17 via invariant natural killer T cell-dependent mechanisms."xsd:string |
| http://purl.uniprot.org/citations/19700760 | http://purl.org/dc/terms/identifier | "doi:10.2353/ajpath.2009.090265"xsd:string |
| http://purl.uniprot.org/citations/19700760 | http://purl.uniprot.org/core/author | "Fujita M."xsd:string |
| http://purl.uniprot.org/citations/19700760 | http://purl.uniprot.org/core/author | "Miyake S."xsd:string |
| http://purl.uniprot.org/citations/19700760 | http://purl.uniprot.org/core/author | "Mizuno M."xsd:string |
| http://purl.uniprot.org/citations/19700760 | http://purl.uniprot.org/core/author | "Otsuka T."xsd:string |
| http://purl.uniprot.org/citations/19700760 | http://purl.uniprot.org/core/author | "Yamamura T."xsd:string |
| http://purl.uniprot.org/citations/19700760 | http://purl.uniprot.org/core/author | "Tomi C."xsd:string |
| http://purl.uniprot.org/citations/19700760 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19700760 | http://purl.uniprot.org/core/name | "Am J Pathol"xsd:string |
| http://purl.uniprot.org/citations/19700760 | http://purl.uniprot.org/core/pages | "1116-1123"xsd:string |
| http://purl.uniprot.org/citations/19700760 | http://purl.uniprot.org/core/title | "Carcinoembryonic antigen-related cell adhesion molecule 1 modulates experimental autoimmune encephalomyelitis via an iNKT cell-dependent mechanism."xsd:string |
| http://purl.uniprot.org/citations/19700760 | http://purl.uniprot.org/core/volume | "175"xsd:string |
| http://purl.uniprot.org/citations/19700760 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19700760 |
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