| http://purl.uniprot.org/citations/19704118 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19704118 | http://www.w3.org/2000/01/rdf-schema#comment | "Approximately 5% to 10% of diffuse large B-cell lymphomas (DLBCLs) harbor an MYC oncogene rearrangement (MYC+). The prognostic significance of MYC+ DLBCL was determined in an unselected population of patients with newly diagnosed DLBCL treated with rituximab in combination with cyclophosphamide, doxorubicin, vincristine, and prednisone chemotherapy (R-CHOP). Using a Vysis break-apart fluorescence in situ hybridization probe, 12 of 135 (8.8%) cases of MYC+ DLBCL were identified that had no defining high-risk features. MYC+ DLBCL was associated with an inferior 5-year progression-free survival (66% vs 31%, P = .006) and overall survival (72% vs 33%, P = .016). Multivariate analysis confirmed the prognostic importance of MYC for both progression-free survival (hazard ratio = 3.28; 95% confidence interval, 1.49-7.21, P = .003) and overall survival (hazard ratio = 2.98; 95% confidence interval, 1.28-6.95, P = .011). Cases of MYC+ DLBCL also had a higher risk of central nervous system relapse (P = .023), independent of other risk factors. The diagnosis of MYC+ DLBCL is likely underappreciated; and given the lack of defining risk factors, fluorescence in situ hybridization for MYC rearrangements should be performed in all patients with DLBCL. In the R-CHOP treatment era, MYC+ DLBCLs have an inferior prognosis. Treatment regimens similar to those used in Burkitt lymphoma may be more appropriate in this patient population and need to be prospectively tested."xsd:string |
| http://purl.uniprot.org/citations/19704118 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2009-05-220095"xsd:string |
| http://purl.uniprot.org/citations/19704118 | http://purl.uniprot.org/core/author | "Gascoyne R.D."xsd:string |
| http://purl.uniprot.org/citations/19704118 | http://purl.uniprot.org/core/author | "Connors J.M."xsd:string |
| http://purl.uniprot.org/citations/19704118 | http://purl.uniprot.org/core/author | "Horsman D.E."xsd:string |
| http://purl.uniprot.org/citations/19704118 | http://purl.uniprot.org/core/author | "Johnson N.A."xsd:string |
| http://purl.uniprot.org/citations/19704118 | http://purl.uniprot.org/core/author | "Ben-Neriah S."xsd:string |
| http://purl.uniprot.org/citations/19704118 | http://purl.uniprot.org/core/author | "Savage K.J."xsd:string |
| http://purl.uniprot.org/citations/19704118 | http://purl.uniprot.org/core/author | "Farinha P."xsd:string |
| http://purl.uniprot.org/citations/19704118 | http://purl.uniprot.org/core/author | "Sehn L.H."xsd:string |
| http://purl.uniprot.org/citations/19704118 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19704118 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/19704118 | http://purl.uniprot.org/core/pages | "3533-3537"xsd:string |
| http://purl.uniprot.org/citations/19704118 | http://purl.uniprot.org/core/title | "MYC gene rearrangements are associated with a poor prognosis in diffuse large B-cell lymphoma patients treated with R-CHOP chemotherapy."xsd:string |
| http://purl.uniprot.org/citations/19704118 | http://purl.uniprot.org/core/volume | "114"xsd:string |
| http://purl.uniprot.org/citations/19704118 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19704118 |
| http://purl.uniprot.org/citations/19704118 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19704118 |
| http://purl.uniprot.org/uniprot/#_A0A0B4J1R1-mappedCitation-19704118 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19704118 |
| http://purl.uniprot.org/uniprot/#_A0N2G3-mappedCitation-19704118 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19704118 |
| http://purl.uniprot.org/uniprot/#_A0A224B085-mappedCitation-19704118 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19704118 |
| http://purl.uniprot.org/uniprot/#_B3CJ86-mappedCitation-19704118 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19704118 |
| http://purl.uniprot.org/uniprot/#_B3CJ87-mappedCitation-19704118 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19704118 |
| http://purl.uniprot.org/uniprot/#_B3CJ88-mappedCitation-19704118 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19704118 |
| http://purl.uniprot.org/uniprot/#_B3CJB3-mappedCitation-19704118 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19704118 |