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http://purl.uniprot.org/citations/19705434http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/19705434http://www.w3.org/2000/01/rdf-schema#comment"For the establishment of a fully functional septated heart, addition of myocardium from second heart field-derived structures is important. Platelet-derived growth factors (PDGFs) are known for their role in cardiovascular development. In this study, we aim to elucidate this role of PDGF-A, PDGF-C, and their receptor PDGFR-alpha. We analyzed the expression patterns of PDGF-A, -C, and their receptor PDGFR-alpha during avian heart development. A spatiotemporal pattern of ligands was seen with colocalization of the PDGFR-alpha. This was found in second heart field-derived myocardium as well as the proepicardial organ (PEO) and epicardium. Mechanical inhibition of epicardial outgrowth as well as chemical disturbance of PDGFR-alpha support a functional role of the ligands and the receptor in cardiac development."xsd:string
http://purl.uniprot.org/citations/19705434http://purl.org/dc/terms/identifier"doi:10.1002/dvdy.22073"xsd:string
http://purl.uniprot.org/citations/19705434http://purl.uniprot.org/core/author"Poelmann R.E."xsd:string
http://purl.uniprot.org/citations/19705434http://purl.uniprot.org/core/author"Maas S."xsd:string
http://purl.uniprot.org/citations/19705434http://purl.uniprot.org/core/author"Gittenberger-de Groot A.C."xsd:string
http://purl.uniprot.org/citations/19705434http://purl.uniprot.org/core/author"Lie-Venema H."xsd:string
http://purl.uniprot.org/citations/19705434http://purl.uniprot.org/core/author"Bleyl S.B."xsd:string
http://purl.uniprot.org/citations/19705434http://purl.uniprot.org/core/author"Van Den Akker N.M."xsd:string
http://purl.uniprot.org/citations/19705434http://purl.uniprot.org/core/author"Vicente-Steijn R."xsd:string
http://purl.uniprot.org/citations/19705434http://purl.uniprot.org/core/author"Bax N.A."xsd:string
http://purl.uniprot.org/citations/19705434http://purl.uniprot.org/core/date"2009"xsd:gYear
http://purl.uniprot.org/citations/19705434http://purl.uniprot.org/core/name"Dev Dyn"xsd:string
http://purl.uniprot.org/citations/19705434http://purl.uniprot.org/core/pages"2658-2669"xsd:string
http://purl.uniprot.org/citations/19705434http://purl.uniprot.org/core/title"Platelet-derived growth factor is involved in the differentiation of second heart field-derived cardiac structures in chicken embryos."xsd:string
http://purl.uniprot.org/citations/19705434http://purl.uniprot.org/core/volume"238"xsd:string
http://purl.uniprot.org/citations/19705434http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/19705434
http://purl.uniprot.org/citations/19705434http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/19705434
http://purl.uniprot.org/uniprot/#_Q9PUF6-mappedCitation-19705434http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/19705434
http://purl.uniprot.org/uniprot/#_Q9PUF7-mappedCitation-19705434http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/19705434
http://purl.uniprot.org/uniprot/#_Q9YI43-mappedCitation-19705434http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/19705434
http://purl.uniprot.org/uniprot/#_Q90WK1-mappedCitation-19705434http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/19705434
http://purl.uniprot.org/uniprot/#_Q90WK2-mappedCitation-19705434http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/19705434
http://purl.uniprot.org/uniprot/#_Q90WK3-mappedCitation-19705434http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/19705434
http://purl.uniprot.org/uniprot/#_Q90ZJ3-mappedCitation-19705434http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/19705434