| http://purl.uniprot.org/citations/19706554 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19706554 | http://www.w3.org/2000/01/rdf-schema#comment | "Ca(2+) influx by store-operated Ca(2+) influx channels (SOCs) mediates many cellular functions regulated by Ca(2+), and excessive SOC-mediated Ca(2+) influx is cytotoxic and associated with disease. One form of SOC is the CRAC current that is mediated by Orai channels activated by STIM1. A fundamental property of the native CRAC and of the Orais is fast Ca(2+)-dependent inactivation, which limits Ca(2+) influx to guard against cellular damage. The molecular mechanism of this essential regulatory mechanism is unknown. We report here the fast Ca(2+)-dependent inactivation is mediated by three conserved glutamates in the C termini (CT) of Orai2 and Orai3, which show prominent fast Ca(2+)-dependent inactivation compared with Orai1. Transfer of the CT between the Orais transfers both the extent of channel opening and the mode of fast Ca(2+)-dependent inactivation. Fast Ca(2+)-dependent inactivation of the Orais also requires a domain of STIM1; fragments of STIM1 that efficiently open Orai channels do not evoke fast inactivation unless they include an anionic sequence that is C-terminal to the STIM1-Orai activating region (SOAR). Our studies suggest that Orai CT are necessary and sufficient to control pore opening and uncover the molecular mechanism of fast Ca(2+)-dependent inactivation that has implications for Ca(2+) influx by SOC in physiological and pathological states."xsd:string |
| http://purl.uniprot.org/citations/19706554 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0904664106"xsd:string |
| http://purl.uniprot.org/citations/19706554 | http://purl.uniprot.org/core/author | "Lee K.P."xsd:string |
| http://purl.uniprot.org/citations/19706554 | http://purl.uniprot.org/core/author | "Zeng W."xsd:string |
| http://purl.uniprot.org/citations/19706554 | http://purl.uniprot.org/core/author | "Muallem S."xsd:string |
| http://purl.uniprot.org/citations/19706554 | http://purl.uniprot.org/core/author | "Worley P.F."xsd:string |
| http://purl.uniprot.org/citations/19706554 | http://purl.uniprot.org/core/author | "So I."xsd:string |
| http://purl.uniprot.org/citations/19706554 | http://purl.uniprot.org/core/author | "Yuan J.P."xsd:string |
| http://purl.uniprot.org/citations/19706554 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19706554 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/19706554 | http://purl.uniprot.org/core/pages | "14687-14692"xsd:string |
| http://purl.uniprot.org/citations/19706554 | http://purl.uniprot.org/core/title | "Molecular determinants of fast Ca2+-dependent inactivation and gating of the Orai channels."xsd:string |
| http://purl.uniprot.org/citations/19706554 | http://purl.uniprot.org/core/volume | "106"xsd:string |
| http://purl.uniprot.org/citations/19706554 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19706554 |
| http://purl.uniprot.org/citations/19706554 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19706554 |
| http://purl.uniprot.org/uniprot/#_G0XQ39-mappedCitation-19706554 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19706554 |
| http://purl.uniprot.org/uniprot/#_B4DUB4-mappedCitation-19706554 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19706554 |
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| http://purl.uniprot.org/uniprot/#_Q9BRQ5-mappedCitation-19706554 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19706554 |
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