| http://purl.uniprot.org/citations/19706684 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19706684 | http://www.w3.org/2000/01/rdf-schema#comment | "Stimulation of astrocytes with epidermal growth factor (EGF) induced proliferation and triggered the biosynthesis of the transcription factor Egr-1, involving the activation of the extracellular signal-regulated protein kinase (ERK) signaling pathway. No differences in the proliferation rate of astrocytes prepared from wild-type or Egr-1-deficient mice were detected. However, expression of a dominant-negative mutant of Egr-1 that interfered with DNA-binding of all Egr proteins prevented EGF-induced proliferation of astrocytes. Site-directed mutagenesis of two crucial cysteine residues within the zinc finger DNA-binding domain revealed that DNA-binding of the Egr-1 mutant was essential to inhibit proliferation of EGF-stimulated astrocytes. Expression of NAB2 (a negative co-regulator of Egr-1, Egr-2 and Egr-3) or a dominant-negative mutant of Elk-1 (a key regulator of Egr-1 biosynthesis) abolished EGF-induced proliferation of astrocytes. Chromatin immunoprecipitation experiments showed that Egr-1, Egr-2 and Egr-3 bound to the gene expressing basic fibroblast growth factor (bFGF) in EGF-stimulated astrocytes. Egr-2 and Egr-3 also interacted with the bFGF gene in EGF-stimulated astrocytes prepared from Egr-1-deficient mice, indicating that loss of Egr-1 is compensated by other Egr proteins. Together, these data show that Egr transcription factors are essential for conversion of the mitogenic signal of EGF into a proliferative response."xsd:string |
| http://purl.uniprot.org/citations/19706684 | http://purl.org/dc/terms/identifier | "doi:10.1242/jcs.048272"xsd:string |
| http://purl.uniprot.org/citations/19706684 | http://purl.uniprot.org/core/author | "Charnay P."xsd:string |
| http://purl.uniprot.org/citations/19706684 | http://purl.uniprot.org/core/author | "Endo T."xsd:string |
| http://purl.uniprot.org/citations/19706684 | http://purl.uniprot.org/core/author | "Thiel G."xsd:string |
| http://purl.uniprot.org/citations/19706684 | http://purl.uniprot.org/core/author | "Rossler O.G."xsd:string |
| http://purl.uniprot.org/citations/19706684 | http://purl.uniprot.org/core/author | "Mayer S.I."xsd:string |
| http://purl.uniprot.org/citations/19706684 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19706684 | http://purl.uniprot.org/core/name | "J Cell Sci"xsd:string |
| http://purl.uniprot.org/citations/19706684 | http://purl.uniprot.org/core/pages | "3340-3350"xsd:string |
| http://purl.uniprot.org/citations/19706684 | http://purl.uniprot.org/core/title | "Epidermal-growth-factor-induced proliferation of astrocytes requires Egr transcription factors."xsd:string |
| http://purl.uniprot.org/citations/19706684 | http://purl.uniprot.org/core/volume | "122"xsd:string |
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