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http://purl.uniprot.org/citations/19710009http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/19710009http://www.w3.org/2000/01/rdf-schema#comment"Growth-blocking peptide (GBP) is a hormone-like peptide that suppresses the growth of the host armyworm. Although the 23-amino acid GBP (1-23 GBP) is expressed in nonparasitized armyworm plasma, the parasitization by wasp produces the 28-amino acid GBP (1-28 GBP) through an elongation of the C-terminal amino acid sequence. In this study, we characterized the GBP variants, which consist of various lengths of the C-terminal region, by comparing their biological activities and three-dimensional structures. The results of an injection study indicate that 1-28 GBP most strongly suppresses larval growth. NMR analysis shows that these peptides have basically the same tertiary structures and that the extension of the C-terminal region is disordered. However, the C-terminal region of 1-28 GBP undergoes a conformational transition from a random coiled state to an alpha-helical state in the presence of dodecylphosphocholine micelles. This suggests that binding of the C-terminal region would affect larval growth activity."xsd:string
http://purl.uniprot.org/citations/19710009http://purl.org/dc/terms/identifier"doi:10.1074/jbc.m109.011148"xsd:string
http://purl.uniprot.org/citations/19710009http://purl.uniprot.org/core/author"Kawano K."xsd:string
http://purl.uniprot.org/citations/19710009http://purl.uniprot.org/core/author"Mizuguchi M."xsd:string
http://purl.uniprot.org/citations/19710009http://purl.uniprot.org/core/author"Yamamoto H."xsd:string
http://purl.uniprot.org/citations/19710009http://purl.uniprot.org/core/author"Kamiya M."xsd:string
http://purl.uniprot.org/citations/19710009http://purl.uniprot.org/core/author"Aizawa T."xsd:string
http://purl.uniprot.org/citations/19710009http://purl.uniprot.org/core/author"Umetsu Y."xsd:string
http://purl.uniprot.org/citations/19710009http://purl.uniprot.org/core/author"Hayakawa Y."xsd:string
http://purl.uniprot.org/citations/19710009http://purl.uniprot.org/core/author"Demura M."xsd:string
http://purl.uniprot.org/citations/19710009http://purl.uniprot.org/core/author"Kumaki Y."xsd:string
http://purl.uniprot.org/citations/19710009http://purl.uniprot.org/core/author"Muto K."xsd:string
http://purl.uniprot.org/citations/19710009http://purl.uniprot.org/core/date"2009"xsd:gYear
http://purl.uniprot.org/citations/19710009http://purl.uniprot.org/core/name"J Biol Chem"xsd:string
http://purl.uniprot.org/citations/19710009http://purl.uniprot.org/core/pages"29625-29634"xsd:string
http://purl.uniprot.org/citations/19710009http://purl.uniprot.org/core/title"C-terminal elongation of growth-blocking peptide enhances its biological activity and micelle binding affinity."xsd:string
http://purl.uniprot.org/citations/19710009http://purl.uniprot.org/core/volume"284"xsd:string
http://purl.uniprot.org/citations/19710009http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/19710009
http://purl.uniprot.org/citations/19710009http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/19710009
http://purl.uniprot.org/uniprot/#_Q27913-mappedCitation-19710009http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/19710009
http://purl.uniprot.org/uniprot/Q27913http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/19710009