| http://purl.uniprot.org/citations/19710174 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19710174 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19710174 | http://www.w3.org/2000/01/rdf-schema#comment | "Mitogen-inducible gene 6 [Mig-6; Errfi1 (ErbB receptor feedback inhibitor 1); RALT (receptor-associated late transducer); gene 33] is a ubiquitously expressed adaptor protein containing CRIB, SH3 and 14-3-3 interacting domains and has been shown to negatively regulate EGF signaling. Ablation of Mig-6 results in a partial lethal phenotype in which surviving mice acquire degenerative joint diseases and tumors in multiple organs. We have determined that the early lethality in Mig-6(-/-) mice occurs in the perinatal period, with mice displaying abnormal lung development. Histological examination of Mig-6(-/-) lungs (E15.5-P3) revealed reduced septation, airway over-branching, alveolar type II cell hyperplasia, and disturbed vascular formation. In neonatal Mig-6(-/-) lungs, cell proliferation increased in the airway epithelium but apoptosis increased in the blood vessels. Adult Mig-6(-/-) mice developed features of chronic obstructive pulmonary disease (COPD); however, when Mig-6 was inducibly ablated in adult mice (Mig-6(d/d)), the lungs were normal. Knockdown of MIG-6 in H441 human bronchiolar epithelial cells increased phospho-EGFR and phospho-AKT levels as well as cell proliferation, whereas knockdown of MIG-6 in human lung microvascular endothelial (HMVEC-L) cells promoted their apoptosis. These results demonstrate that Mig-6 is required for prenatal and perinatal lung development, in part through the regulation of EGF signaling, as well as for maintaining proper pulmonary vascularization."xsd:string |
| http://purl.uniprot.org/citations/19710174 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.032979"xsd:string |
| http://purl.uniprot.org/citations/19710174 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.032979"xsd:string |
| http://purl.uniprot.org/citations/19710174 | http://purl.uniprot.org/core/author | "Yang Y."xsd:string |
| http://purl.uniprot.org/citations/19710174 | http://purl.uniprot.org/core/author | "Yang Y."xsd:string |
| http://purl.uniprot.org/citations/19710174 | http://purl.uniprot.org/core/author | "Ludwig T."xsd:string |
| http://purl.uniprot.org/citations/19710174 | http://purl.uniprot.org/core/author | "Ludwig T."xsd:string |
| http://purl.uniprot.org/citations/19710174 | http://purl.uniprot.org/core/author | "Cho S.N."xsd:string |
| http://purl.uniprot.org/citations/19710174 | http://purl.uniprot.org/core/author | "Cho S.N."xsd:string |
| http://purl.uniprot.org/citations/19710174 | http://purl.uniprot.org/core/author | "Smith Y."xsd:string |
| http://purl.uniprot.org/citations/19710174 | http://purl.uniprot.org/core/author | "Smith Y."xsd:string |
| http://purl.uniprot.org/citations/19710174 | http://purl.uniprot.org/core/author | "Jin N."xsd:string |
| http://purl.uniprot.org/citations/19710174 | http://purl.uniprot.org/core/author | "Jin N."xsd:string |
| http://purl.uniprot.org/citations/19710174 | http://purl.uniprot.org/core/author | "Kurie J.M."xsd:string |
| http://purl.uniprot.org/citations/19710174 | http://purl.uniprot.org/core/author | "Kurie J.M."xsd:string |
| http://purl.uniprot.org/citations/19710174 | http://purl.uniprot.org/core/author | "Evans C.M."xsd:string |
| http://purl.uniprot.org/citations/19710174 | http://purl.uniprot.org/core/author | "Evans C.M."xsd:string |
| http://purl.uniprot.org/citations/19710174 | http://purl.uniprot.org/core/author | "Jeong J.W."xsd:string |
| http://purl.uniprot.org/citations/19710174 | http://purl.uniprot.org/core/author | "Jeong J.W."xsd:string |
| http://purl.uniprot.org/citations/19710174 | http://purl.uniprot.org/core/author | "DeMayo F.J."xsd:string |
| http://purl.uniprot.org/citations/19710174 | http://purl.uniprot.org/core/author | "DeMayo F.J."xsd:string |
| http://purl.uniprot.org/citations/19710174 | http://purl.uniprot.org/core/author | "Yen R."xsd:string |
| http://purl.uniprot.org/citations/19710174 | http://purl.uniprot.org/core/author | "Yen R."xsd:string |