| http://purl.uniprot.org/citations/1971269 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1971269 | http://www.w3.org/2000/01/rdf-schema#comment | "HLA-DP polymorphism was examined among celiac disease patients and controls. Restriction fragment length polymorphism (RFLP) genotyping showed a significant association of DPw1 in celiac disease (32/80) compared with controls (6/53, p = 0.0002). DPw1 typing by RFLP was verified using DPB1-amplified DNA and an oligonucleotide probe specific for the DPw1-associated DPB1 gene. The RFLP-assigned DPw1 genotype corresponded closely to the binding pattern of the sequence-specific oligonucleotide probe, although discrepancies did occur. The association between celiac disease and DPw1, however, remained. Oligonucleotide probe specificity was confirmed by sequencing DPB1-amplified DNA from four DPw1-genotyped celiacs. DPw1 is only present in celiacs who genotype DR3a-positive. Of DR3a controls 24% are DPw1-positive compared with 5% of non-DR3a controls (p = 0.03), suggesting that an extended DR3a, DPw1 haplotype occurs in the control population. This haplotype forms a large proportion of the DR3a haplotypes predisposing to celiac disease. Alternatively, DPw1 may represent an independent risk factor inherited in linkage with HLA-DR3 and -DQw2. Although predisposition to celiac disease is likely to be mediated by a specific DQ alpha/DQ beta heterodimer, a direct role for the DPw1 antigen cannot be discounted."xsd:string |
| http://purl.uniprot.org/citations/1971269 | http://purl.org/dc/terms/identifier | "doi:10.1016/0198-8859(90)90052-q"xsd:string |
| http://purl.uniprot.org/citations/1971269 | http://purl.uniprot.org/core/author | "Welsh K.I."xsd:string |
| http://purl.uniprot.org/citations/1971269 | http://purl.uniprot.org/core/author | "Lanchbury J.S."xsd:string |
| http://purl.uniprot.org/citations/1971269 | http://purl.uniprot.org/core/author | "Hall M.A."xsd:string |
| http://purl.uniprot.org/citations/1971269 | http://purl.uniprot.org/core/author | "Ciclitira P.J."xsd:string |
| http://purl.uniprot.org/citations/1971269 | http://purl.uniprot.org/core/author | "Bolsover W.J."xsd:string |
| http://purl.uniprot.org/citations/1971269 | http://purl.uniprot.org/core/date | "1990"xsd:gYear |
| http://purl.uniprot.org/citations/1971269 | http://purl.uniprot.org/core/name | "Hum Immunol"xsd:string |
| http://purl.uniprot.org/citations/1971269 | http://purl.uniprot.org/core/pages | "220-228"xsd:string |
| http://purl.uniprot.org/citations/1971269 | http://purl.uniprot.org/core/title | "Celiac disease is associated with an extended HLA-DR3 haplotype which includes HLA-DPw1."xsd:string |
| http://purl.uniprot.org/citations/1971269 | http://purl.uniprot.org/core/volume | "27"xsd:string |
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