| http://purl.uniprot.org/citations/19713529 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19713529 | http://www.w3.org/2000/01/rdf-schema#comment | "MicroRNAs are a class of sophisticated regulators of gene expression, acting as post-transcriptional inhibitors that recognize their target mRNAs through base pairing with short regions along the 3'UTRs. Several microRNAs are tissue specific, suggesting a specialized role in tissue differentiation or maintenance, and quite a few are critically involved in tumorigenesis. We studied miR-128, a brain-enriched microRNA, in retinoic acid-differentiated neuroblastoma cells, and we found that this microRNA is up-regulated in treated cells, where it down-modulates the expression of two proteins involved in the migratory potential of neural cells: Reelin and DCX. Consistently, miR-128 ectopic overexpression suppressed Reelin and DCX, whereas the LNA antisense-mediated miR-128 knockdown caused the two proteins to increase. Ectopic miR-128 overexpression reduced neuroblastoma cell motility and invasiveness, and impaired cell growth. Finally, the analysis of a small series of primary human neuroblastomas showed an association between high levels of miR-128 expression and favorable features, such as favorable Shimada category or very young age at diagnosis. Thus, we provide evidence for a role for miR-128 in the molecular events modulating neuroblastoma progression and aggressiveness."xsd:string |
| http://purl.uniprot.org/citations/19713529 | http://purl.org/dc/terms/identifier | "doi:10.1096/fj.09-134965"xsd:string |
| http://purl.uniprot.org/citations/19713529 | http://purl.uniprot.org/core/author | "Giannini G."xsd:string |
| http://purl.uniprot.org/citations/19713529 | http://purl.uniprot.org/core/author | "Galardi S."xsd:string |
| http://purl.uniprot.org/citations/19713529 | http://purl.uniprot.org/core/author | "Gulino A."xsd:string |
| http://purl.uniprot.org/citations/19713529 | http://purl.uniprot.org/core/author | "Evangelisti C."xsd:string |
| http://purl.uniprot.org/citations/19713529 | http://purl.uniprot.org/core/author | "Ciafre S.A."xsd:string |
| http://purl.uniprot.org/citations/19713529 | http://purl.uniprot.org/core/author | "Farace M.G."xsd:string |
| http://purl.uniprot.org/citations/19713529 | http://purl.uniprot.org/core/author | "Massimi I."xsd:string |
| http://purl.uniprot.org/citations/19713529 | http://purl.uniprot.org/core/author | "Massalini S."xsd:string |
| http://purl.uniprot.org/citations/19713529 | http://purl.uniprot.org/core/author | "Dominici C."xsd:string |
| http://purl.uniprot.org/citations/19713529 | http://purl.uniprot.org/core/author | "McDowell H.P."xsd:string |
| http://purl.uniprot.org/citations/19713529 | http://purl.uniprot.org/core/author | "Bue M.C."xsd:string |
| http://purl.uniprot.org/citations/19713529 | http://purl.uniprot.org/core/author | "Florian M.C."xsd:string |
| http://purl.uniprot.org/citations/19713529 | http://purl.uniprot.org/core/author | "Messi E."xsd:string |
| http://purl.uniprot.org/citations/19713529 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19713529 | http://purl.uniprot.org/core/name | "FASEB J"xsd:string |
| http://purl.uniprot.org/citations/19713529 | http://purl.uniprot.org/core/pages | "4276-4287"xsd:string |
| http://purl.uniprot.org/citations/19713529 | http://purl.uniprot.org/core/title | "MiR-128 up-regulation inhibits Reelin and DCX expression and reduces neuroblastoma cell motility and invasiveness."xsd:string |
| http://purl.uniprot.org/citations/19713529 | http://purl.uniprot.org/core/volume | "23"xsd:string |
| http://purl.uniprot.org/citations/19713529 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19713529 |
| http://purl.uniprot.org/citations/19713529 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19713529 |
| http://purl.uniprot.org/uniprot/#_A8K340-mappedCitation-19713529 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19713529 |
| http://purl.uniprot.org/uniprot/#_B4DSM9-mappedCitation-19713529 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19713529 |