| http://purl.uniprot.org/citations/19715685 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19715685 | http://www.w3.org/2000/01/rdf-schema#comment | "N-Acylethanolamines (NAEs) constitute a family of endogenous bioactive lipids that includes arachidonoylethanolamide (anandamide), palmitoylethanolamide (PEA) and oleoylethanolamide (OEA). These lipids are formed from their respective N-acylated ethanolamine phospholipid (NAPE) precursor by the action of a phospholipase D enzyme (NAPE-PLD). Anandamide, OEA, and PEA are all bioactive lipids that may influence, amongst others: neuroinflammation, food intake, and oocyte implantation. Here we have synthesized a number of NAPE analogues with variation in the phosphoester structure. The NAPE analogues as well as selected phospholipids and beta-lactamase substrates were tested as potential modifiers of cloned human NAPE-PLD in an enzyme assay involving a (14)C-labeled diether-NAPE substrate. One hit was identified, namely 1,2-dihexanoyl-glycero-N-(3-(tetradecanoylamino)propyl)phosphoramidate (AHP-71B) which showed inhibitory activity and may serve as template for further structure-activity developments. Furthermore, it was found that NAPE-PLD was activated by phosphatidylethanolamine and inhibited by the beta-lactamase substrate nitrocefin."xsd:string |
| http://purl.uniprot.org/citations/19715685 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.chemphyslip.2009.08.005"xsd:string |
| http://purl.uniprot.org/citations/19715685 | http://purl.uniprot.org/core/author | "Petersen G."xsd:string |
| http://purl.uniprot.org/citations/19715685 | http://purl.uniprot.org/core/author | "Pedersen A.H."xsd:string |
| http://purl.uniprot.org/citations/19715685 | http://purl.uniprot.org/core/author | "Pickering D.S."xsd:string |
| http://purl.uniprot.org/citations/19715685 | http://purl.uniprot.org/core/author | "Hansen H.S."xsd:string |
| http://purl.uniprot.org/citations/19715685 | http://purl.uniprot.org/core/author | "Begtrup M."xsd:string |
| http://purl.uniprot.org/citations/19715685 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19715685 | http://purl.uniprot.org/core/name | "Chem Phys Lipids"xsd:string |
| http://purl.uniprot.org/citations/19715685 | http://purl.uniprot.org/core/pages | "53-61"xsd:string |
| http://purl.uniprot.org/citations/19715685 | http://purl.uniprot.org/core/title | "Effect of synthetic and natural phospholipids on N-acylphosphatidylethanolamine-hydrolyzing phospholipase D activity."xsd:string |
| http://purl.uniprot.org/citations/19715685 | http://purl.uniprot.org/core/volume | "162"xsd:string |
| http://purl.uniprot.org/citations/19715685 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19715685 |
| http://purl.uniprot.org/citations/19715685 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19715685 |
| http://purl.uniprot.org/uniprot/#_B4E3B0-mappedCitation-19715685 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19715685 |
| http://purl.uniprot.org/uniprot/#_Q4G0T7-mappedCitation-19715685 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19715685 |
| http://purl.uniprot.org/uniprot/#_Q6IQ20-mappedCitation-19715685 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19715685 |
| http://purl.uniprot.org/uniprot/Q4G0T7 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19715685 |
| http://purl.uniprot.org/uniprot/Q6IQ20 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19715685 |
| http://purl.uniprot.org/uniprot/B4E3B0 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19715685 |