| http://purl.uniprot.org/citations/19716369 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19716369 | http://www.w3.org/2000/01/rdf-schema#comment | "Epinephrine inhibits insulin release by activation of K(+) channels and subsequent hyperpolarization of pancreatic beta cells. The present study explored whether epinephrine-induced hyperpolarization is modified by phosphatidylinositol 3-kinase (PI3K) and phosphatidylinositide-dependent kinase PDK1. Perforated patch-clamp was performed in islet cells isolated from PDK1 hypomorphic mice (pdk1(fl/fl)), expressing only 20% of PDK1, and in their wild-type littermates. At 16.8mM glucose, the cell membrane was hyperpolarized by epinephrine (1 microM), an effect significantly blunted in pdk1(fl/fl) and abrogated in wild-type cells by inhibition of PI3K with wortmannin (100 nM) or LY294002 (10 microM). The hyperpolarizing effect of epinephrine in pancreatic islet cells is thus sensitive to PI3K and PDK1."xsd:string |
| http://purl.uniprot.org/citations/19716369 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.febslet.2009.08.027"xsd:string |
| http://purl.uniprot.org/citations/19716369 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/19716369 | http://purl.uniprot.org/core/author | "Lang F."xsd:string |
| http://purl.uniprot.org/citations/19716369 | http://purl.uniprot.org/core/author | "Ullrich S."xsd:string |
| http://purl.uniprot.org/citations/19716369 | http://purl.uniprot.org/core/author | "Haring H.U."xsd:string |
| http://purl.uniprot.org/citations/19716369 | http://purl.uniprot.org/core/author | "Shumilina E."xsd:string |
| http://purl.uniprot.org/citations/19716369 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19716369 | http://purl.uniprot.org/core/name | "FEBS Lett"xsd:string |
| http://purl.uniprot.org/citations/19716369 | http://purl.uniprot.org/core/pages | "3101-3106"xsd:string |
| http://purl.uniprot.org/citations/19716369 | http://purl.uniprot.org/core/title | "Epinephrine-induced hyperpolarization of pancreatic islet cells is sensitive to PI3K-PDK1 signaling."xsd:string |
| http://purl.uniprot.org/citations/19716369 | http://purl.uniprot.org/core/volume | "583"xsd:string |
| http://purl.uniprot.org/citations/19716369 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19716369 |
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| http://purl.uniprot.org/uniprot/#_F2Z3X6-mappedCitation-19716369 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19716369 |
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| http://purl.uniprot.org/uniprot/#_F2Z3Z9-mappedCitation-19716369 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19716369 |
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| http://purl.uniprot.org/uniprot/#_Q3UHZ0-mappedCitation-19716369 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19716369 |
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