| http://purl.uniprot.org/citations/19716732 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19716732 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19716732 | http://www.w3.org/2000/01/rdf-schema#comment | "Circadian rhythmicity and sleep homeostasis contribute to sleep phenotypes and sleep-wake disorders, some of the genetic determinants of which are emerging. Approximately 10% of the population are homozygous for the 5-repeat allele (PER3(5/5)) of a variable number tandem repeat polymorphism in the clock gene PERIOD3 (PER3). We review recent data on the effects of this polymorphism on sleep-wake regulation. PER3(5/5) are more likely to show morning preference, whereas homozygosity for the four-repeat allele (PER3(4/4)) associates with evening preferences. The association between sleep timing and the circadian rhythms of melatonin and PER3 RNA in leukocytes is stronger in PER3(5/5) than in PER3(4/4). EEG alpha activity in REM sleep, theta/alpha activity during wakefulness and slow wave activity in NREM sleep are elevated in PER3(5/5). PER3(5/5) show a greater cognitive decline, and a greater reduction in fMRI-assessed brain responses to an executive task, in response to total sleep deprivation. These effects are most pronounced during the late circadian night/early morning hours, i.e., approximately 0-4h after the crest of the melatonin rhythm. We interpret the effects of the PER3 polymorphism within the context of a conceptual model in which higher homeostatic sleep pressure in PER3(5/5) through feedback onto the circadian pacemaker modulates the amplitude of diurnal variation in performance. These findings highlight the interrelatedness of circadian rhythmicity and sleep homeostasis."xsd:string |
| http://purl.uniprot.org/citations/19716732 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.smrv.2009.07.002"xsd:string |
| http://purl.uniprot.org/citations/19716732 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.smrv.2009.07.002"xsd:string |
| http://purl.uniprot.org/citations/19716732 | http://purl.uniprot.org/core/author | "Archer S.N."xsd:string |
| http://purl.uniprot.org/citations/19716732 | http://purl.uniprot.org/core/author | "Archer S.N."xsd:string |
| http://purl.uniprot.org/citations/19716732 | http://purl.uniprot.org/core/author | "Dijk D.J."xsd:string |
| http://purl.uniprot.org/citations/19716732 | http://purl.uniprot.org/core/author | "Dijk D.J."xsd:string |
| http://purl.uniprot.org/citations/19716732 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/19716732 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/19716732 | http://purl.uniprot.org/core/name | "Sleep Med. Rev."xsd:string |
| http://purl.uniprot.org/citations/19716732 | http://purl.uniprot.org/core/name | "Sleep Med. Rev."xsd:string |
| http://purl.uniprot.org/citations/19716732 | http://purl.uniprot.org/core/pages | "151-160"xsd:string |
| http://purl.uniprot.org/citations/19716732 | http://purl.uniprot.org/core/pages | "151-160"xsd:string |
| http://purl.uniprot.org/citations/19716732 | http://purl.uniprot.org/core/title | "PERIOD3, circadian phenotypes, and sleep homeostasis."xsd:string |
| http://purl.uniprot.org/citations/19716732 | http://purl.uniprot.org/core/title | "PERIOD3, circadian phenotypes, and sleep homeostasis."xsd:string |
| http://purl.uniprot.org/citations/19716732 | http://purl.uniprot.org/core/volume | "14"xsd:string |
| http://purl.uniprot.org/citations/19716732 | http://purl.uniprot.org/core/volume | "14"xsd:string |
| http://purl.uniprot.org/citations/19716732 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19716732 |
| http://purl.uniprot.org/citations/19716732 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19716732 |
| http://purl.uniprot.org/citations/19716732 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19716732 |
| http://purl.uniprot.org/citations/19716732 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19716732 |
| http://purl.uniprot.org/uniprot/P56645 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/19716732 |
| http://purl.uniprot.org/uniprot/P56645#attribution-1CC44BAFD082787533467435F734E346 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19716732 |