| http://purl.uniprot.org/citations/19716793 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19716793 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19716793 | http://www.w3.org/2000/01/rdf-schema#comment | "Bacterial translation elongation factor G (EF-G) catalyzes translocation during peptide elongation and mediates ribosomal disassembly during ribosome recycling in concert with the ribosomal recycling factor (RRF). Two homologs of EF-G have been identified in mitochondria from yeast to man, EF-G1mt and EF-G2mt. Here, we demonstrate that the dual function of bacterial EF-G is divided between EF-G1mt and EF-G2mt in human mitochondria (RRFmt). EF-G1mt specifically catalyzes translocation, whereas EF-G2mt mediates ribosome recycling with human mitochondrial RRF but lacks translocation activity. Domain swapping experiments suggest that the functional specificity for EF-G2mt resides in domains III and IV. Furthermore, GTP hydrolysis by EF-G2mt is not necessary for ribosomal splitting, in contrast to the bacterial-recycling mode. Because EF-G2mt represents a class of translational GTPase that is involved in ribosome recycling, we propose to rename this factor mitochondrial ribosome recycling factor 2 (RRF2mt)."xsd:string |
| http://purl.uniprot.org/citations/19716793 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2009.06.028"xsd:string |
| http://purl.uniprot.org/citations/19716793 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2009.06.028"xsd:string |
| http://purl.uniprot.org/citations/19716793 | http://purl.uniprot.org/core/author | "Ito K."xsd:string |
| http://purl.uniprot.org/citations/19716793 | http://purl.uniprot.org/core/author | "Ito K."xsd:string |
| http://purl.uniprot.org/citations/19716793 | http://purl.uniprot.org/core/author | "Morita H."xsd:string |
| http://purl.uniprot.org/citations/19716793 | http://purl.uniprot.org/core/author | "Morita H."xsd:string |
| http://purl.uniprot.org/citations/19716793 | http://purl.uniprot.org/core/author | "Takeuchi N."xsd:string |
| http://purl.uniprot.org/citations/19716793 | http://purl.uniprot.org/core/author | "Takeuchi N."xsd:string |
| http://purl.uniprot.org/citations/19716793 | http://purl.uniprot.org/core/author | "Ueda T."xsd:string |
| http://purl.uniprot.org/citations/19716793 | http://purl.uniprot.org/core/author | "Ueda T."xsd:string |
| http://purl.uniprot.org/citations/19716793 | http://purl.uniprot.org/core/author | "Nierhaus K.H."xsd:string |
| http://purl.uniprot.org/citations/19716793 | http://purl.uniprot.org/core/author | "Nierhaus K.H."xsd:string |
| http://purl.uniprot.org/citations/19716793 | http://purl.uniprot.org/core/author | "Akama K."xsd:string |
| http://purl.uniprot.org/citations/19716793 | http://purl.uniprot.org/core/author | "Akama K."xsd:string |
| http://purl.uniprot.org/citations/19716793 | http://purl.uniprot.org/core/author | "Tsuboi M."xsd:string |
| http://purl.uniprot.org/citations/19716793 | http://purl.uniprot.org/core/author | "Tsuboi M."xsd:string |
| http://purl.uniprot.org/citations/19716793 | http://purl.uniprot.org/core/author | "Nozaki Y."xsd:string |
| http://purl.uniprot.org/citations/19716793 | http://purl.uniprot.org/core/author | "Nozaki Y."xsd:string |
| http://purl.uniprot.org/citations/19716793 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19716793 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19716793 | http://purl.uniprot.org/core/name | "Mol. Cell"xsd:string |
| http://purl.uniprot.org/citations/19716793 | http://purl.uniprot.org/core/name | "Mol. Cell"xsd:string |