| http://purl.uniprot.org/citations/19718030 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19718030 | http://www.w3.org/2000/01/rdf-schema#comment | "Cooperation between different innate signaling pathways induced by pattern-recognition receptors (PRRs) on dendritic cells (DCs) is crucial for tailoring adaptive immunity to pathogens. Here we show that carbohydrate-specific signaling through the C-type lectin DC-SIGN tailored cytokine production in response to distinct pathogens. DC-SIGN was constitutively associated with a signalosome complex consisting of the scaffold proteins LSP1, KSR1 and CNK and the kinase Raf-1. Mannose-expressing Mycobacterium tuberculosis and human immunodeficiency virus type 1 (HIV-1) induced the recruitment of effector proteins to the DC-SIGN signalosome to activate Raf-1, whereas fucose-expressing pathogens such as Helicobacter pylori actively dissociated the KSR1-CNK-Raf-1 complex from the DC-SIGN signalosome. This dynamic regulation of the signalosome by mannose- and fucose-expressing pathogens led to the enhancement or suppression of proinflammatory responses, respectively. Our study reveals another level of plasticity in tailoring adaptive immunity to pathogens."xsd:string |
| http://purl.uniprot.org/citations/19718030 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni.1778"xsd:string |
| http://purl.uniprot.org/citations/19718030 | http://purl.uniprot.org/core/author | "Geijtenbeek T.B."xsd:string |
| http://purl.uniprot.org/citations/19718030 | http://purl.uniprot.org/core/author | "den Dunnen J."xsd:string |
| http://purl.uniprot.org/citations/19718030 | http://purl.uniprot.org/core/author | "Gringhuis S.I."xsd:string |
| http://purl.uniprot.org/citations/19718030 | http://purl.uniprot.org/core/author | "Litjens M."xsd:string |
| http://purl.uniprot.org/citations/19718030 | http://purl.uniprot.org/core/author | "van der Vlist M."xsd:string |
| http://purl.uniprot.org/citations/19718030 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19718030 | http://purl.uniprot.org/core/name | "Nat Immunol"xsd:string |
| http://purl.uniprot.org/citations/19718030 | http://purl.uniprot.org/core/pages | "1081-1088"xsd:string |
| http://purl.uniprot.org/citations/19718030 | http://purl.uniprot.org/core/title | "Carbohydrate-specific signaling through the DC-SIGN signalosome tailors immunity to Mycobacterium tuberculosis, HIV-1 and Helicobacter pylori."xsd:string |
| http://purl.uniprot.org/citations/19718030 | http://purl.uniprot.org/core/volume | "10"xsd:string |
| http://purl.uniprot.org/citations/19718030 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19718030 |
| http://purl.uniprot.org/citations/19718030 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19718030 |
| http://purl.uniprot.org/uniprot/#_A8K2L4-mappedCitation-19718030 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19718030 |
| http://purl.uniprot.org/uniprot/#_A0A0H4PIN7-mappedCitation-19718030 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19718030 |
| http://purl.uniprot.org/uniprot/#_A0A0H4PJU2-mappedCitation-19718030 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19718030 |
| http://purl.uniprot.org/uniprot/#_A0A0H4PJU9-mappedCitation-19718030 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19718030 |
| http://purl.uniprot.org/uniprot/#_A0A0H4PMS7-mappedCitation-19718030 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19718030 |
| http://purl.uniprot.org/uniprot/#_A0A0H4Q180-mappedCitation-19718030 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19718030 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z4L5-mappedCitation-19718030 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19718030 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z559-mappedCitation-19718030 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19718030 |
| http://purl.uniprot.org/uniprot/#_B2R907-mappedCitation-19718030 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19718030 |
| http://purl.uniprot.org/uniprot/#_A8K7L8-mappedCitation-19718030 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19718030 |